Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data

Lineage tracing studies combining CRISPR-Cas9 editing and scRNA-seq face several challenges and cannot integrate lineages from multiple individuals. Here the authors show that integration of mutation and expression leads to accurate lineage tree inference and enables the learning of a species-invari...

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Autores principales:	Hamim Zafar, Chieh Lin, Ziv Bar-Joseph
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/daaf125f03e44badb4ee8cf03dfa5e8f
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spelling	oai:doaj.org-article:daaf125f03e44badb4ee8cf03dfa5e8f2021-12-02T16:04:12ZSingle-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data10.1038/s41467-020-16821-52041-1723https://doaj.org/article/daaf125f03e44badb4ee8cf03dfa5e8f2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16821-5https://doaj.org/toc/2041-1723Lineage tracing studies combining CRISPR-Cas9 editing and scRNA-seq face several challenges and cannot integrate lineages from multiple individuals. Here the authors show that integration of mutation and expression leads to accurate lineage tree inference and enables the learning of a species-invariant lineage tree.Hamim ZafarChieh LinZiv Bar-JosephNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hamim Zafar Chieh Lin Ziv Bar-Joseph Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
description	Lineage tracing studies combining CRISPR-Cas9 editing and scRNA-seq face several challenges and cannot integrate lineages from multiple individuals. Here the authors show that integration of mutation and expression leads to accurate lineage tree inference and enables the learning of a species-invariant lineage tree.
format	article
author	Hamim Zafar Chieh Lin Ziv Bar-Joseph
author_facet	Hamim Zafar Chieh Lin Ziv Bar-Joseph
author_sort	Hamim Zafar
title	Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
title_short	Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
title_full	Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
title_fullStr	Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
title_full_unstemmed	Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
title_sort	single-cell lineage tracing by integrating crispr-cas9 mutations with transcriptomic data
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/daaf125f03e44badb4ee8cf03dfa5e8f
work_keys_str_mv	AT hamimzafar singlecelllineagetracingbyintegratingcrisprcas9mutationswithtranscriptomicdata AT chiehlin singlecelllineagetracingbyintegratingcrisprcas9mutationswithtranscriptomicdata AT zivbarjoseph singlecelllineagetracingbyintegratingcrisprcas9mutationswithtranscriptomicdata
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Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data

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