Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data

Lineage tracing studies combining CRISPR-Cas9 editing and scRNA-seq face several challenges and cannot integrate lineages from multiple individuals. Here the authors show that integration of mutation and expression leads to accurate lineage tree inference and enables the learning of a species-invari...

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Autores principales: Hamim Zafar, Chieh Lin, Ziv Bar-Joseph
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/daaf125f03e44badb4ee8cf03dfa5e8f
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