The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis
ESCRT filaments drive the final abscission between two daughter cells but how they physically interact with the membrane is unclear. Using proteomics, the authors show that syndecan-4/syntenin/ALIX couples the ESCRT machinery to the abscission site and thus promotes efficient abscission.
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Nature Portfolio
2020
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oai:doaj.org-article:daaf4a7748684ea4ad11e849c544f9752021-12-02T14:42:50ZThe Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis10.1038/s41467-020-15205-z2041-1723https://doaj.org/article/daaf4a7748684ea4ad11e849c544f9752020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15205-zhttps://doaj.org/toc/2041-1723ESCRT filaments drive the final abscission between two daughter cells but how they physically interact with the membrane is unclear. Using proteomics, the authors show that syndecan-4/syntenin/ALIX couples the ESCRT machinery to the abscission site and thus promotes efficient abscission.Cyril AddiAdrien PresleStéphane FrémontFrédérique CuvelierMurielle RocancourtFlorine MilinSandrine SchmutzJulia Chamot-RookeThibaut DouchéMagalie DuchateauQuentin Giai GianettoAudrey SallesHervé MénagerMariette MatondoPascale ZimmermannNeetu Gupta-RossiArnaud EchardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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| topic |
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| spellingShingle |
Science Q Cyril Addi Adrien Presle Stéphane Frémont Frédérique Cuvelier Murielle Rocancourt Florine Milin Sandrine Schmutz Julia Chamot-Rooke Thibaut Douché Magalie Duchateau Quentin Giai Gianetto Audrey Salles Hervé Ménager Mariette Matondo Pascale Zimmermann Neetu Gupta-Rossi Arnaud Echard The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis |
| description |
ESCRT filaments drive the final abscission between two daughter cells but how they physically interact with the membrane is unclear. Using proteomics, the authors show that syndecan-4/syntenin/ALIX couples the ESCRT machinery to the abscission site and thus promotes efficient abscission. |
| format |
article |
| author |
Cyril Addi Adrien Presle Stéphane Frémont Frédérique Cuvelier Murielle Rocancourt Florine Milin Sandrine Schmutz Julia Chamot-Rooke Thibaut Douché Magalie Duchateau Quentin Giai Gianetto Audrey Salles Hervé Ménager Mariette Matondo Pascale Zimmermann Neetu Gupta-Rossi Arnaud Echard |
| author_facet |
Cyril Addi Adrien Presle Stéphane Frémont Frédérique Cuvelier Murielle Rocancourt Florine Milin Sandrine Schmutz Julia Chamot-Rooke Thibaut Douché Magalie Duchateau Quentin Giai Gianetto Audrey Salles Hervé Ménager Mariette Matondo Pascale Zimmermann Neetu Gupta-Rossi Arnaud Echard |
| author_sort |
Cyril Addi |
| title |
The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis |
| title_short |
The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis |
| title_full |
The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis |
| title_fullStr |
The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis |
| title_full_unstemmed |
The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis |
| title_sort |
flemmingsome reveals an escrt-to-membrane coupling via alix/syntenin/syndecan-4 required for completion of cytokinesis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/daaf4a7748684ea4ad11e849c544f975 |
| work_keys_str_mv |
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