Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model

Natural and synthetic polycations of different kinds attract substantial attention due to an increasing number of their applications in the biomedical industry and in pharmacology. The key characteristic determining the effectiveness of the majority of these applications is the number of macromolecu...

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Autores principales:	Rodion J. Molotkovsky, Timur R. Galimzyanov, Yury A. Ermakov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lipid membrane liposome lipid monolayer polycation adsorption polylysine electrokinetic potential Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/dab469ccdf0f49a990c34a1e7715514f
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spelling	oai:doaj.org-article:dab469ccdf0f49a990c34a1e7715514f2021-11-11T18:09:15ZHeterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model10.3390/ma142166231996-1944https://doaj.org/article/dab469ccdf0f49a990c34a1e7715514f2021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/21/6623https://doaj.org/toc/1996-1944Natural and synthetic polycations of different kinds attract substantial attention due to an increasing number of their applications in the biomedical industry and in pharmacology. The key characteristic determining the effectiveness of the majority of these applications is the number of macromolecules adsorbed on the surface of biological cells or their lipid models. Their study is complicated by a possible heterogeneity of polymer layer adsorbed on the membrane. Experimental methods reflecting the structure of the layer include the electrokinetic measurements in liposome suspension and the boundary potential of planar bilayer lipid membranes (BLM) and lipid monolayers with a mixed composition of lipids and the ionic media. In the review, we systematically analyze the methods of experimental registration and theoretical description of the laterally heterogeneous structures in the polymer layer published in the literature and in our previous studies. In particular, we consider a model based on classical theory of the electrical double layer, used to analyze the available data of the electrokinetic measurements in liposome suspension with polylysines of varying molecular mass. This model suggests a few parameters related to the heterogeneity of the polymer layer and allows determining the conditions for its appearance at the membrane surface. A further development of this theoretical approach is discussed.Rodion J. MolotkovskyTimur R. GalimzyanovYury A. ErmakovMDPI AGarticlelipid membraneliposomelipid monolayerpolycation adsorptionpolylysineelectrokinetic potentialTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6623, p 6623 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipid membrane liposome lipid monolayer polycation adsorption polylysine electrokinetic potential Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	lipid membrane liposome lipid monolayer polycation adsorption polylysine electrokinetic potential Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Rodion J. Molotkovsky Timur R. Galimzyanov Yury A. Ermakov Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model
description	Natural and synthetic polycations of different kinds attract substantial attention due to an increasing number of their applications in the biomedical industry and in pharmacology. The key characteristic determining the effectiveness of the majority of these applications is the number of macromolecules adsorbed on the surface of biological cells or their lipid models. Their study is complicated by a possible heterogeneity of polymer layer adsorbed on the membrane. Experimental methods reflecting the structure of the layer include the electrokinetic measurements in liposome suspension and the boundary potential of planar bilayer lipid membranes (BLM) and lipid monolayers with a mixed composition of lipids and the ionic media. In the review, we systematically analyze the methods of experimental registration and theoretical description of the laterally heterogeneous structures in the polymer layer published in the literature and in our previous studies. In particular, we consider a model based on classical theory of the electrical double layer, used to analyze the available data of the electrokinetic measurements in liposome suspension with polylysines of varying molecular mass. This model suggests a few parameters related to the heterogeneity of the polymer layer and allows determining the conditions for its appearance at the membrane surface. A further development of this theoretical approach is discussed.
format	article
author	Rodion J. Molotkovsky Timur R. Galimzyanov Yury A. Ermakov
author_facet	Rodion J. Molotkovsky Timur R. Galimzyanov Yury A. Ermakov
author_sort	Rodion J. Molotkovsky
title	Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model
title_short	Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model
title_full	Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model
title_fullStr	Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model
title_full_unstemmed	Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model
title_sort	heterogeneity in lateral distribution of polycations at the surface of lipid membrane: from the experimental data to the theoretical model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dab469ccdf0f49a990c34a1e7715514f
work_keys_str_mv	AT rodionjmolotkovsky heterogeneityinlateraldistributionofpolycationsatthesurfaceoflipidmembranefromtheexperimentaldatatothetheoreticalmodel AT timurrgalimzyanov heterogeneityinlateraldistributionofpolycationsatthesurfaceoflipidmembranefromtheexperimentaldatatothetheoreticalmodel AT yuryaermakov heterogeneityinlateraldistributionofpolycationsatthesurfaceoflipidmembranefromtheexperimentaldatatothetheoreticalmodel
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Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model

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