Higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms

Abstract It is not fully established whether leukocyte can predict the poor outcome for ruptured cerebral aneurysms (CA) or not. Here, we retrospectively analyzed the clinical data of 428 patients with ruptured CA between 2010 and 2015. Patients’ demographic data, including gender, age, history of s...

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Autores principales:	Pei-Sen Yao, Guo-Rong Chen, Xue-Ling Xie, Huang-Cheng Shang-Guan, Jin-Zhen Gao, Yuan-Xiang Lin, Shu-Fa Zheng, Zhang-Ya Lin, De-Zhi Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dab5730fa18e4546bbb5c72a8cbc9af1
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spelling	oai:doaj.org-article:dab5730fa18e4546bbb5c72a8cbc9af12021-12-02T15:08:12ZHigher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms10.1038/s41598-018-23934-x2045-2322https://doaj.org/article/dab5730fa18e4546bbb5c72a8cbc9af12018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23934-xhttps://doaj.org/toc/2045-2322Abstract It is not fully established whether leukocyte can predict the poor outcome for ruptured cerebral aneurysms (CA) or not. Here, we retrospectively analyzed the clinical data of 428 patients with ruptured CA between 2010 and 2015. Patients’ demographic data, including gender, age, history of smoking, alcohol, hypertension, diabetes and hypercholesterolemia, Hunt-Hess and Fisher grade, occurrence of hydrocephalus, aneurysm location, time to surgery, delayed ischemic neurological deficit (DIND) and peak leukocyte of blood test from day 1 to 3 after aneurysmal rupture were recorded and analyzed. In the multivariable analysis model, gender, Fisher grade, time to surgery and hydrocephalus were not relevant to poor outcome. However, Hunt-Hess grade, DIND and preoperative leukocyte count (>13.84 × 109/L) were significantly associated with adverse outcome. The respective increased risks were 5.2- (OR 5.24, 95% CI 1.67–16.50, p = 0.005), 6.2-(OR 6.24, 95% CI 3.55–10.99, p < 0.001) and 10.9-fold (OR 10.93, 95% CI 5.98–19.97, p < 0.001). The study revealed that Hunt-Hess grade, DIND and preoperative leukocyte count (>13.84 × 109/L) were independent risk factors for poor outcome of ruptured CA at 3 months. Higher leukocyte count is a convenient and useful marker to predict 3-month poor outcome for ruptured CA.Pei-Sen YaoGuo-Rong ChenXue-Ling XieHuang-Cheng Shang-GuanJin-Zhen GaoYuan-Xiang LinShu-Fa ZhengZhang-Ya LinDe-Zhi KangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pei-Sen Yao Guo-Rong Chen Xue-Ling Xie Huang-Cheng Shang-Guan Jin-Zhen Gao Yuan-Xiang Lin Shu-Fa Zheng Zhang-Ya Lin De-Zhi Kang Higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms
description	Abstract It is not fully established whether leukocyte can predict the poor outcome for ruptured cerebral aneurysms (CA) or not. Here, we retrospectively analyzed the clinical data of 428 patients with ruptured CA between 2010 and 2015. Patients’ demographic data, including gender, age, history of smoking, alcohol, hypertension, diabetes and hypercholesterolemia, Hunt-Hess and Fisher grade, occurrence of hydrocephalus, aneurysm location, time to surgery, delayed ischemic neurological deficit (DIND) and peak leukocyte of blood test from day 1 to 3 after aneurysmal rupture were recorded and analyzed. In the multivariable analysis model, gender, Fisher grade, time to surgery and hydrocephalus were not relevant to poor outcome. However, Hunt-Hess grade, DIND and preoperative leukocyte count (>13.84 × 109/L) were significantly associated with adverse outcome. The respective increased risks were 5.2- (OR 5.24, 95% CI 1.67–16.50, p = 0.005), 6.2-(OR 6.24, 95% CI 3.55–10.99, p < 0.001) and 10.9-fold (OR 10.93, 95% CI 5.98–19.97, p < 0.001). The study revealed that Hunt-Hess grade, DIND and preoperative leukocyte count (>13.84 × 109/L) were independent risk factors for poor outcome of ruptured CA at 3 months. Higher leukocyte count is a convenient and useful marker to predict 3-month poor outcome for ruptured CA.
format	article
author	Pei-Sen Yao Guo-Rong Chen Xue-Ling Xie Huang-Cheng Shang-Guan Jin-Zhen Gao Yuan-Xiang Lin Shu-Fa Zheng Zhang-Ya Lin De-Zhi Kang
author_facet	Pei-Sen Yao Guo-Rong Chen Xue-Ling Xie Huang-Cheng Shang-Guan Jin-Zhen Gao Yuan-Xiang Lin Shu-Fa Zheng Zhang-Ya Lin De-Zhi Kang
author_sort	Pei-Sen Yao
title	Higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms
title_short	Higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms
title_full	Higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms
title_fullStr	Higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms
title_full_unstemmed	Higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms
title_sort	higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dab5730fa18e4546bbb5c72a8cbc9af1
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Higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms

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