Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena throu...

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Autores principales:	Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D. Müller, Matthias H. Tschöp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/daba42e8bc934c15ab731e4faf7ff42c
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spelling	oai:doaj.org-article:daba42e8bc934c15ab731e4faf7ff42c2021-12-02T14:40:07ZCoordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes10.1038/s41467-018-06769-y2041-1723https://doaj.org/article/daba42e8bc934c15ab731e4faf7ff42c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06769-yhttps://doaj.org/toc/2041-1723Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena through small-molecule combination therapy, and show that this treatment improves metabolic health of obese mice.Christoffer ClemmensenSigrid JallMaximilian KleinertCarmelo QuartaTim GruberJosefine ReberStephan SachsKatrin FischerAnnette FeuchtingerAngelos KarlasStephanie E. SimondsGerald GrandlDaniela LoherEva Sanchez-QuantSusanne KeipertMartin JastrochSusanna M. HofmannEmmani B. M. NascimentoPatrick SchrauwenVasilis NtziachristosMichael A. CowleyBrian FinanTimo D. MüllerMatthias H. TschöpNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christoffer Clemmensen Sigrid Jall Maximilian Kleinert Carmelo Quarta Tim Gruber Josefine Reber Stephan Sachs Katrin Fischer Annette Feuchtinger Angelos Karlas Stephanie E. Simonds Gerald Grandl Daniela Loher Eva Sanchez-Quant Susanne Keipert Martin Jastroch Susanna M. Hofmann Emmani B. M. Nascimento Patrick Schrauwen Vasilis Ntziachristos Michael A. Cowley Brian Finan Timo D. Müller Matthias H. Tschöp Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
description	Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena through small-molecule combination therapy, and show that this treatment improves metabolic health of obese mice.
format	article
author	Christoffer Clemmensen Sigrid Jall Maximilian Kleinert Carmelo Quarta Tim Gruber Josefine Reber Stephan Sachs Katrin Fischer Annette Feuchtinger Angelos Karlas Stephanie E. Simonds Gerald Grandl Daniela Loher Eva Sanchez-Quant Susanne Keipert Martin Jastroch Susanna M. Hofmann Emmani B. M. Nascimento Patrick Schrauwen Vasilis Ntziachristos Michael A. Cowley Brian Finan Timo D. Müller Matthias H. Tschöp
author_facet	Christoffer Clemmensen Sigrid Jall Maximilian Kleinert Carmelo Quarta Tim Gruber Josefine Reber Stephan Sachs Katrin Fischer Annette Feuchtinger Angelos Karlas Stephanie E. Simonds Gerald Grandl Daniela Loher Eva Sanchez-Quant Susanne Keipert Martin Jastroch Susanna M. Hofmann Emmani B. M. Nascimento Patrick Schrauwen Vasilis Ntziachristos Michael A. Cowley Brian Finan Timo D. Müller Matthias H. Tschöp
author_sort	Christoffer Clemmensen
title	Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
title_short	Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
title_full	Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
title_fullStr	Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
title_full_unstemmed	Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
title_sort	coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/daba42e8bc934c15ab731e4faf7ff42c
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Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

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