Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Neuronal activity is known to increase myelination by oligodendrocytes in the mouse brain. Here, Mitew et al. demonstrate that chemogenetic manipulations of somatosensory axon activity both increase the generation of new oligodendrocytes and preferentially enhance myelination of the activated axons.

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Detalles Bibliográficos
Autores principales: Stanislaw Mitew, Ilan Gobius, Laura R. Fenlon, Stuart J. McDougall, David Hawkes, Yao Lulu Xing, Helena Bujalka, Andrew L. Gundlach, Linda J. Richards, Trevor J. Kilpatrick, Tobias D. Merson, Ben Emery
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/dabe9ec425ca41538111396c6350e1d3
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Sumario:Neuronal activity is known to increase myelination by oligodendrocytes in the mouse brain. Here, Mitew et al. demonstrate that chemogenetic manipulations of somatosensory axon activity both increase the generation of new oligodendrocytes and preferentially enhance myelination of the activated axons.