Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Neuronal activity is known to increase myelination by oligodendrocytes in the mouse brain. Here, Mitew et al. demonstrate that chemogenetic manipulations of somatosensory axon activity both increase the generation of new oligodendrocytes and preferentially enhance myelination of the activated axons.

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Autores principales:	Stanislaw Mitew, Ilan Gobius, Laura R. Fenlon, Stuart J. McDougall, David Hawkes, Yao Lulu Xing, Helena Bujalka, Andrew L. Gundlach, Linda J. Richards, Trevor J. Kilpatrick, Tobias D. Merson, Ben Emery
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dabe9ec425ca41538111396c6350e1d3
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spelling	oai:doaj.org-article:dabe9ec425ca41538111396c6350e1d32021-12-02T17:31:27ZPharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner10.1038/s41467-017-02719-22041-1723https://doaj.org/article/dabe9ec425ca41538111396c6350e1d32018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02719-2https://doaj.org/toc/2041-1723Neuronal activity is known to increase myelination by oligodendrocytes in the mouse brain. Here, Mitew et al. demonstrate that chemogenetic manipulations of somatosensory axon activity both increase the generation of new oligodendrocytes and preferentially enhance myelination of the activated axons.Stanislaw MitewIlan GobiusLaura R. FenlonStuart J. McDougallDavid HawkesYao Lulu XingHelena BujalkaAndrew L. GundlachLinda J. RichardsTrevor J. KilpatrickTobias D. MersonBen EmeryNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stanislaw Mitew Ilan Gobius Laura R. Fenlon Stuart J. McDougall David Hawkes Yao Lulu Xing Helena Bujalka Andrew L. Gundlach Linda J. Richards Trevor J. Kilpatrick Tobias D. Merson Ben Emery Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
description	Neuronal activity is known to increase myelination by oligodendrocytes in the mouse brain. Here, Mitew et al. demonstrate that chemogenetic manipulations of somatosensory axon activity both increase the generation of new oligodendrocytes and preferentially enhance myelination of the activated axons.
format	article
author	Stanislaw Mitew Ilan Gobius Laura R. Fenlon Stuart J. McDougall David Hawkes Yao Lulu Xing Helena Bujalka Andrew L. Gundlach Linda J. Richards Trevor J. Kilpatrick Tobias D. Merson Ben Emery
author_facet	Stanislaw Mitew Ilan Gobius Laura R. Fenlon Stuart J. McDougall David Hawkes Yao Lulu Xing Helena Bujalka Andrew L. Gundlach Linda J. Richards Trevor J. Kilpatrick Tobias D. Merson Ben Emery
author_sort	Stanislaw Mitew
title	Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
title_short	Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
title_full	Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
title_fullStr	Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
title_full_unstemmed	Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
title_sort	pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dabe9ec425ca41538111396c6350e1d3
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Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

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