Reirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival

Whole brain radiotherapy (WBRT) for brain metastases (BMs) was considered to be dose limited. Reirradiation of WBRT for recurrent BM has always been challenged. Here, we report a patient with multiple BMs of non-small-cell lung cancer (NSCLC), who received two courses of WBRT at the interval of 5 ye...

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Autores principales:	Minmin Li, Yanbo Song, Longhao Li, Jian Qin, Hongbin Deng, Tao Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	reirradiation whole brain radiotherapy lung cancer brain metastasis long survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/dac05d6af1a046acaee161e517037422
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spelling	oai:doaj.org-article:dac05d6af1a046acaee161e5170374222021-12-01T04:38:07ZReirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival2234-943X10.3389/fonc.2021.780581https://doaj.org/article/dac05d6af1a046acaee161e5170374222021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.780581/fullhttps://doaj.org/toc/2234-943XWhole brain radiotherapy (WBRT) for brain metastases (BMs) was considered to be dose limited. Reirradiation of WBRT for recurrent BM has always been challenged. Here, we report a patient with multiple BMs of non-small-cell lung cancer (NSCLC), who received two courses of WBRT at the interval of 5 years with the cumulative administration dose for whole brain as 70 Gy and a boost for the local site as 30 Gy. Furthermore, after experiencing relapse in the brain, he underwent extra gamma knife (GK) radiotherapy for local brain metastasis for the third time after 5 years. The overall survival was 12 years since he was initially diagnosed with NSCLC with multiple brain metastases. Meanwhile, each time of radiotherapy brought a good tumor response to brain metastasis. Outstandingly, during the whole survival, he had a good quality of life (QoL) with Karnofsky Performance Score (KPS) above 80. Even after the last GK was executed, he had just a mild neurocognitive defect. In conclusion, with the cautious evaluation of a patient, we suggest that reirradiation of WBRT could be a choice, and the cumulative radiation dose of the brain may be individually modified.Minmin LiYanbo SongLonghao LiJian QinHongbin DengTao ZhangFrontiers Media S.A.articlereirradiationwhole brain radiotherapylung cancerbrain metastasislong survivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reirradiation whole brain radiotherapy lung cancer brain metastasis long survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	reirradiation whole brain radiotherapy lung cancer brain metastasis long survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Minmin Li Yanbo Song Longhao Li Jian Qin Hongbin Deng Tao Zhang Reirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival
description	Whole brain radiotherapy (WBRT) for brain metastases (BMs) was considered to be dose limited. Reirradiation of WBRT for recurrent BM has always been challenged. Here, we report a patient with multiple BMs of non-small-cell lung cancer (NSCLC), who received two courses of WBRT at the interval of 5 years with the cumulative administration dose for whole brain as 70 Gy and a boost for the local site as 30 Gy. Furthermore, after experiencing relapse in the brain, he underwent extra gamma knife (GK) radiotherapy for local brain metastasis for the third time after 5 years. The overall survival was 12 years since he was initially diagnosed with NSCLC with multiple brain metastases. Meanwhile, each time of radiotherapy brought a good tumor response to brain metastasis. Outstandingly, during the whole survival, he had a good quality of life (QoL) with Karnofsky Performance Score (KPS) above 80. Even after the last GK was executed, he had just a mild neurocognitive defect. In conclusion, with the cautious evaluation of a patient, we suggest that reirradiation of WBRT could be a choice, and the cumulative radiation dose of the brain may be individually modified.
format	article
author	Minmin Li Yanbo Song Longhao Li Jian Qin Hongbin Deng Tao Zhang
author_facet	Minmin Li Yanbo Song Longhao Li Jian Qin Hongbin Deng Tao Zhang
author_sort	Minmin Li
title	Reirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival
title_short	Reirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival
title_full	Reirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival
title_fullStr	Reirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival
title_full_unstemmed	Reirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival
title_sort	reirradiation of whole brain for recurrent brain metastases: a case report of lung cancer with 12-year survival
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/dac05d6af1a046acaee161e517037422
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Reirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival

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