Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time

Joo Hyung Lee,1 Keyoung Jin Chun,2 Han Sung Kim,3 Sang Ho Kim,4 Kwon-Yong Lee,1,6 Dae Jun Kim,5,6 Dohyung Lim,1,61Department of Mechanical Engineering, Sejong University, Seoul, Republic of Korea; 2Gerontechnology R & D Group, Korea Institute of Industrial Technology, Cheonan, Chungnam, Repu...

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Autores principales:	Lee JH, Chun KJ, Kim HS, Kim SH, Lee K-Y, Kim DJ, Lim D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Rheumatoid arthritis In vivo micro-computed tomography periodic microarchitecture alteration pattern Trabecular bone thickness distribution Trabecular bone separation distribution Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/dac2018a47464df0b3c75afcfb9ce49e
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spelling	oai:doaj.org-article:dac2018a47464df0b3c75afcfb9ce49e2021-12-02T02:18:27ZChanges in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time1178-1998https://doaj.org/article/dac2018a47464df0b3c75afcfb9ce49e2012-09-01T00:00:00Zhttps://www.dovepress.com/changes-in-microarchitectural-characteristics-at-the-tibial-epiphysis--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Joo Hyung Lee,1 Keyoung Jin Chun,2 Han Sung Kim,3 Sang Ho Kim,4 Kwon-Yong Lee,1,6 Dae Jun Kim,5,6 Dohyung Lim,1,61Department of Mechanical Engineering, Sejong University, Seoul, Republic of Korea; 2Gerontechnology R & D Group, Korea Institute of Industrial Technology, Cheonan, Chungnam, Republic of Korea; 3Department of Biomedical Engineering, Yonsei University, Wonju, Gangwon, Republic of Korea; 4Department of Bioengineering and Department of Surgery, National University of Singapore, Singapore; 5Department of Advanced Material Engineering, 6Bioengineering Research Center, Sejong University, Seoul, Republic of KoreaBackground: Little is known about the time course of changes in the microarchitecture of the tibial epiphysis with rheumatoid arthritis (RA), although such information would be valuable in predicting risk of fracture. Therefore, we used in vivo microcomputed tomography (µ-CT) to assess patterns of microarchitectural alterations in the tibial epiphysis using collagen-induced RA in an animal model.Methods: Bovine type II collagen was injected intradermally into the tails of rats for induction of RA. The tibial joints were scanned by in vivo µ-CT at 0, 4, and 8 weeks following injection. Microarchitectural parameters were measured to evaluate alteration patterns of bone microarchitecture at the tibial epiphysis.Results: The microarchitectural alterations in an RA group were significantly different from those in a control group from 0 to 4 weeks and from 4 to 8 weeks following injection (P < 0.05). The distribution of trabecular bone thickness and trabecular bone separation from 0 weeks to 8 weeks differed significantly (P < 0.05).Conclusion: These results indicate that the patterns of microarchitectural alterations at the tibial epiphysis are strongly affected by collagen-induced progression of RA and entail a severe risk of fracture at the tibial epiphysis. This study represents a valuable first approach to tracking periodic and continuous changes in the microarchitectural characteristics of the tibial epiphysis with collagen-induced RA.Keywords: collagen-induced rheumatoid arthritis, in vivo microcomputed tomography, periodic microarchitecture alteration pattern, trabecular bone thickness, trabecular bone separationLee JHChun KJKim HSKim SHLee K-YKim DJLim DDove Medical PressarticleRheumatoid arthritisIn vivo micro-computed tomographyperiodic microarchitecture alteration patternTrabecular bone thickness distributionTrabecular bone separation distributionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 7, Pp 373-382 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rheumatoid arthritis In vivo micro-computed tomography periodic microarchitecture alteration pattern Trabecular bone thickness distribution Trabecular bone separation distribution Geriatrics RC952-954.6
spellingShingle	Rheumatoid arthritis In vivo micro-computed tomography periodic microarchitecture alteration pattern Trabecular bone thickness distribution Trabecular bone separation distribution Geriatrics RC952-954.6 Lee JH Chun KJ Kim HS Kim SH Lee K-Y Kim DJ Lim D Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time
description	Joo Hyung Lee,1 Keyoung Jin Chun,2 Han Sung Kim,3 Sang Ho Kim,4 Kwon-Yong Lee,1,6 Dae Jun Kim,5,6 Dohyung Lim,1,61Department of Mechanical Engineering, Sejong University, Seoul, Republic of Korea; 2Gerontechnology R & D Group, Korea Institute of Industrial Technology, Cheonan, Chungnam, Republic of Korea; 3Department of Biomedical Engineering, Yonsei University, Wonju, Gangwon, Republic of Korea; 4Department of Bioengineering and Department of Surgery, National University of Singapore, Singapore; 5Department of Advanced Material Engineering, 6Bioengineering Research Center, Sejong University, Seoul, Republic of KoreaBackground: Little is known about the time course of changes in the microarchitecture of the tibial epiphysis with rheumatoid arthritis (RA), although such information would be valuable in predicting risk of fracture. Therefore, we used in vivo microcomputed tomography (µ-CT) to assess patterns of microarchitectural alterations in the tibial epiphysis using collagen-induced RA in an animal model.Methods: Bovine type II collagen was injected intradermally into the tails of rats for induction of RA. The tibial joints were scanned by in vivo µ-CT at 0, 4, and 8 weeks following injection. Microarchitectural parameters were measured to evaluate alteration patterns of bone microarchitecture at the tibial epiphysis.Results: The microarchitectural alterations in an RA group were significantly different from those in a control group from 0 to 4 weeks and from 4 to 8 weeks following injection (P < 0.05). The distribution of trabecular bone thickness and trabecular bone separation from 0 weeks to 8 weeks differed significantly (P < 0.05).Conclusion: These results indicate that the patterns of microarchitectural alterations at the tibial epiphysis are strongly affected by collagen-induced progression of RA and entail a severe risk of fracture at the tibial epiphysis. This study represents a valuable first approach to tracking periodic and continuous changes in the microarchitectural characteristics of the tibial epiphysis with collagen-induced RA.Keywords: collagen-induced rheumatoid arthritis, in vivo microcomputed tomography, periodic microarchitecture alteration pattern, trabecular bone thickness, trabecular bone separation
format	article
author	Lee JH Chun KJ Kim HS Kim SH Lee K-Y Kim DJ Lim D
author_facet	Lee JH Chun KJ Kim HS Kim SH Lee K-Y Kim DJ Lim D
author_sort	Lee JH
title	Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time
title_short	Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time
title_full	Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time
title_fullStr	Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time
title_full_unstemmed	Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time
title_sort	changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/dac2018a47464df0b3c75afcfb9ce49e
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Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time

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