Serum Human Epididymis Protein 4 Level is Associated with Cognitive Function in Patients with Diabetes Mellitus

Fengfeng Bai,1,* Tao Li,1,* Baozhu Li,1 Xiaozheng Li,1 Lifeng Zhu2 1Department of Psychiatry, Anding Hospital, Tianjin 300222, People’s Republic of China; 2Nursing Department, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, People’s...

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Autores principales:	Bai F, Li T, Li B, Li X, Zhu L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	human epididymis protein 4 diabetes mellitus cognitive decline prognostic value Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/dac5cd1c591b4612b03c73475a099050
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spelling	oai:doaj.org-article:dac5cd1c591b4612b03c73475a0990502021-12-02T10:29:26ZSerum Human Epididymis Protein 4 Level is Associated with Cognitive Function in Patients with Diabetes Mellitus1178-7007https://doaj.org/article/dac5cd1c591b4612b03c73475a0990502020-10-01T00:00:00Zhttps://www.dovepress.com/serum-human-epididymis-protein-4-level-is-associated-with-cognitive-fu-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Fengfeng Bai,1,* Tao Li,1,* Baozhu Li,1 Xiaozheng Li,1 Lifeng Zhu2 1Department of Psychiatry, Anding Hospital, Tianjin 300222, People’s Republic of China; 2Nursing Department, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lifeng ZhuNursing Department, The Second Hospital, Cheeloo College of Medicine, Shandong University, 247 Beiyuan Street, Jinan, Shandong 250033, People’s Republic of ChinaTel +86 17660087098Email 2814539930@qq.comBackground: Previous studies have reported that patients with diabetes mellitus (DM) have a higher incidence of cognitive decline and an increased risk of developing all types of dementia. The aim was to elucidate the association between serum human epididymal protein 4 and cognitive function in patients with DM.Methods: Serum levels of HE4 were measured in 205 patients with DM. All DM patients were followed up for a median period of 48 months (range=5– 49) prospectively. Cox proportional hazard analysis was used to evaluate the predictive value of serum HE4 for predicting cognitive decline (end point).Results: Multivariate linear regression analysis revealed that serum HE4 was independently associated with MOCA score after adjusting for age, gender, BMI, current smoker, current drinker, admission systolic and diastolic BP, CVD history and laboratory measurements in patients with DM at baseline (Sβ= − 0.120; 95% CI, − 0.151– − 0.069; P< 0.001). The multivariate Cox proportional hazard analysis revealed that serum HE4 (HR=2.408, 95% CI 1.669– 5.238, P< 0.001) was an independent prognostic factor for cognitive decline in these DM patients.Conclusion: Our results showed that serum HE4 was significantly and independently associated with cognitive decline and had independent predictive value for cognitive decline in patients with DM. Serum HE4 might enable early recognition of senile dementia among DM patients.Keywords: human epididymis protein 4, diabetes mellitus, cognitive decline, prognostic valueBai FLi TLi BLi XZhu LDove Medical Pressarticlehuman epididymis protein 4diabetes mellituscognitive declineprognostic valueSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3919-3924 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	human epididymis protein 4 diabetes mellitus cognitive decline prognostic value Specialties of internal medicine RC581-951
spellingShingle	human epididymis protein 4 diabetes mellitus cognitive decline prognostic value Specialties of internal medicine RC581-951 Bai F Li T Li B Li X Zhu L Serum Human Epididymis Protein 4 Level is Associated with Cognitive Function in Patients with Diabetes Mellitus
description	Fengfeng Bai,1,* Tao Li,1,* Baozhu Li,1 Xiaozheng Li,1 Lifeng Zhu2 1Department of Psychiatry, Anding Hospital, Tianjin 300222, People’s Republic of China; 2Nursing Department, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lifeng ZhuNursing Department, The Second Hospital, Cheeloo College of Medicine, Shandong University, 247 Beiyuan Street, Jinan, Shandong 250033, People’s Republic of ChinaTel +86 17660087098Email 2814539930@qq.comBackground: Previous studies have reported that patients with diabetes mellitus (DM) have a higher incidence of cognitive decline and an increased risk of developing all types of dementia. The aim was to elucidate the association between serum human epididymal protein 4 and cognitive function in patients with DM.Methods: Serum levels of HE4 were measured in 205 patients with DM. All DM patients were followed up for a median period of 48 months (range=5– 49) prospectively. Cox proportional hazard analysis was used to evaluate the predictive value of serum HE4 for predicting cognitive decline (end point).Results: Multivariate linear regression analysis revealed that serum HE4 was independently associated with MOCA score after adjusting for age, gender, BMI, current smoker, current drinker, admission systolic and diastolic BP, CVD history and laboratory measurements in patients with DM at baseline (Sβ= − 0.120; 95% CI, − 0.151– − 0.069; P< 0.001). The multivariate Cox proportional hazard analysis revealed that serum HE4 (HR=2.408, 95% CI 1.669– 5.238, P< 0.001) was an independent prognostic factor for cognitive decline in these DM patients.Conclusion: Our results showed that serum HE4 was significantly and independently associated with cognitive decline and had independent predictive value for cognitive decline in patients with DM. Serum HE4 might enable early recognition of senile dementia among DM patients.Keywords: human epididymis protein 4, diabetes mellitus, cognitive decline, prognostic value
format	article
author	Bai F Li T Li B Li X Zhu L
author_facet	Bai F Li T Li B Li X Zhu L
author_sort	Bai F
title	Serum Human Epididymis Protein 4 Level is Associated with Cognitive Function in Patients with Diabetes Mellitus
title_short	Serum Human Epididymis Protein 4 Level is Associated with Cognitive Function in Patients with Diabetes Mellitus
title_full	Serum Human Epididymis Protein 4 Level is Associated with Cognitive Function in Patients with Diabetes Mellitus
title_fullStr	Serum Human Epididymis Protein 4 Level is Associated with Cognitive Function in Patients with Diabetes Mellitus
title_full_unstemmed	Serum Human Epididymis Protein 4 Level is Associated with Cognitive Function in Patients with Diabetes Mellitus
title_sort	serum human epididymis protein 4 level is associated with cognitive function in patients with diabetes mellitus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/dac5cd1c591b4612b03c73475a099050
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Serum Human Epididymis Protein 4 Level is Associated with Cognitive Function in Patients with Diabetes Mellitus

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