Sphingolipid-dependent Dscam sorting regulates axon segregation

Little is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distribution of Dscam for neuronal patterning in Drosop...

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Autores principales: Gaurav Goyal, Junfeng Zheng, Elisabeth Adam, Georg Steffes, Mamta Jain, Kristaps Klavins, Thomas Hummel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/dac65b4ee54f4d37850c41772c6a9f87
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Sumario:Little is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distribution of Dscam for neuronal patterning in Drosophila Mushroom Bodies