TFEB regulates murine liver cell fate during development and regeneration

The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and that its depletion prevents tissue recovery upon in...

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Autores principales:	Nunzia Pastore, Tuong Huynh, Niculin J. Herz, Alessia Calcagni’, Tiemo J. Klisch, Lorenzo Brunetti, Kangho Ho Kim, Marco De Giorgi, Ayrea Hurley, Annamaria Carissimo, Margherita Mutarelli, Niya Aleksieva, Luca D’Orsi, William R. Lagor, David D. Moore, Carmine Settembre, Milton J. Finegold, Stuart J. Forbes, Andrea Ballabio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dac8c6aa736f4598a4966ab084bf32fc
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spelling	oai:doaj.org-article:dac8c6aa736f4598a4966ab084bf32fc2021-12-02T16:49:44ZTFEB regulates murine liver cell fate during development and regeneration10.1038/s41467-020-16300-x2041-1723https://doaj.org/article/dac8c6aa736f4598a4966ab084bf32fc2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16300-xhttps://doaj.org/toc/2041-1723The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and that its depletion prevents tissue recovery upon injury.Nunzia PastoreTuong HuynhNiculin J. HerzAlessia Calcagni’Tiemo J. KlischLorenzo BrunettiKangho Ho KimMarco De GiorgiAyrea HurleyAnnamaria CarissimoMargherita MutarelliNiya AleksievaLuca D’OrsiWilliam R. LagorDavid D. MooreCarmine SettembreMilton J. FinegoldStuart J. ForbesAndrea BallabioNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nunzia Pastore Tuong Huynh Niculin J. Herz Alessia Calcagni’ Tiemo J. Klisch Lorenzo Brunetti Kangho Ho Kim Marco De Giorgi Ayrea Hurley Annamaria Carissimo Margherita Mutarelli Niya Aleksieva Luca D’Orsi William R. Lagor David D. Moore Carmine Settembre Milton J. Finegold Stuart J. Forbes Andrea Ballabio TFEB regulates murine liver cell fate during development and regeneration
description	The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and that its depletion prevents tissue recovery upon injury.
format	article
author	Nunzia Pastore Tuong Huynh Niculin J. Herz Alessia Calcagni’ Tiemo J. Klisch Lorenzo Brunetti Kangho Ho Kim Marco De Giorgi Ayrea Hurley Annamaria Carissimo Margherita Mutarelli Niya Aleksieva Luca D’Orsi William R. Lagor David D. Moore Carmine Settembre Milton J. Finegold Stuart J. Forbes Andrea Ballabio
author_facet	Nunzia Pastore Tuong Huynh Niculin J. Herz Alessia Calcagni’ Tiemo J. Klisch Lorenzo Brunetti Kangho Ho Kim Marco De Giorgi Ayrea Hurley Annamaria Carissimo Margherita Mutarelli Niya Aleksieva Luca D’Orsi William R. Lagor David D. Moore Carmine Settembre Milton J. Finegold Stuart J. Forbes Andrea Ballabio
author_sort	Nunzia Pastore
title	TFEB regulates murine liver cell fate during development and regeneration
title_short	TFEB regulates murine liver cell fate during development and regeneration
title_full	TFEB regulates murine liver cell fate during development and regeneration
title_fullStr	TFEB regulates murine liver cell fate during development and regeneration
title_full_unstemmed	TFEB regulates murine liver cell fate during development and regeneration
title_sort	tfeb regulates murine liver cell fate during development and regeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dac8c6aa736f4598a4966ab084bf32fc
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_version_	1718383244449153024

TFEB regulates murine liver cell fate during development and regeneration

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