White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study

Jae-Min Park,1,2 Hye Sun Lee,3 Ju-Young Park,4 Dong-Hyuk Jung,5 Ji-Won Lee1 1Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea; 2Department of Medicine, Graduate School of Medicine, Yonsei University, Seoul, Republic of Korea;...

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Autores principales:	Park JM, Lee HS, Park JY, Jung DH, Lee JW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	white blood cell count type 2 diabetes mellitus chronic low-grade inflammation non-obese adults Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/daca50f6665f489b8d6e120ffe7a6f52
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spelling	oai:doaj.org-article:daca50f6665f489b8d6e120ffe7a6f522021-12-02T14:24:23ZWhite Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study1178-7031https://doaj.org/article/daca50f6665f489b8d6e120ffe7a6f522021-04-01T00:00:00Zhttps://www.dovepress.com/white-blood-cell-count-as-a-predictor-of-incident-type-2-diabetes-mell-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Jae-Min Park,1,2 Hye Sun Lee,3 Ju-Young Park,4 Dong-Hyuk Jung,5 Ji-Won Lee1 1Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea; 2Department of Medicine, Graduate School of Medicine, Yonsei University, Seoul, Republic of Korea; 3Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea; 4Department of Statistics and Data Science, Yonsei University, Seoul, Republic of Korea; 5Department of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, Gyeonggi-do, Republic of KoreaCorrespondence: Ji-Won LeeDepartment of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of KoreaTel +82 2 2019 3482Fax +82 2 3462 8209Email indi5645@yuhs.acPurpose: Limited evidence is available on whether the white blood cell (WBC) count is a predictor of type 2 diabetes mellitus (T2DM) in non-obese individuals. This study aimed to determine whether WBC count could be used as an indicator for the prediction of incident T2DM among non-obese individuals using a large, community-based Korean cohort that was observed over 10 years.Patients and methods: A total of 4211 non-obese adults without diabetes aged 40– 69 years were selected from the Korean Genome and Epidemiology Study. The participants were divided into four groups according to WBC count quartiles. We prospectively assessed the hazard ratios (HRs) with 95% confidence intervals (CIs) for incident T2DM, based on the American Diabetes Association criteria, using multivariate Cox proportional hazards regression models over 10 years after the baseline survey.Results: During the follow-up period, 592 (14.1%) participants had newly developed T2DM. The higher quartile of WBC count groups showed significantly higher cumulative T2DM incidence over 10 years after the baseline survey (log-rank test, P < 0.001). Compared with the HRs for individuals in the referent lowest quartile, the HR (95% CI) for incident T2DM in individuals in the highest quartile was 1.55 (1.10– 2.18) after adjusting for confounding variables.Conclusion: A higher WBC count predicts future incident T2DM among community-dwelling non-obese Korean adults. This study suggests that WBC count could facilitate the prediction of non-obese individuals susceptible to T2DM.Keywords: white blood cell count, type 2 diabetes mellitus, chronic low-grade inflammation, non-obese adultsPark JMLee HSPark JYJung DHLee JWDove Medical Pressarticlewhite blood cell counttype 2 diabetes mellituschronic low-grade inflammationnon-obese adultsPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 1235-1242 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	white blood cell count type 2 diabetes mellitus chronic low-grade inflammation non-obese adults Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	white blood cell count type 2 diabetes mellitus chronic low-grade inflammation non-obese adults Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Park JM Lee HS Park JY Jung DH Lee JW White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
description	Jae-Min Park,1,2 Hye Sun Lee,3 Ju-Young Park,4 Dong-Hyuk Jung,5 Ji-Won Lee1 1Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea; 2Department of Medicine, Graduate School of Medicine, Yonsei University, Seoul, Republic of Korea; 3Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea; 4Department of Statistics and Data Science, Yonsei University, Seoul, Republic of Korea; 5Department of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, Gyeonggi-do, Republic of KoreaCorrespondence: Ji-Won LeeDepartment of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of KoreaTel +82 2 2019 3482Fax +82 2 3462 8209Email indi5645@yuhs.acPurpose: Limited evidence is available on whether the white blood cell (WBC) count is a predictor of type 2 diabetes mellitus (T2DM) in non-obese individuals. This study aimed to determine whether WBC count could be used as an indicator for the prediction of incident T2DM among non-obese individuals using a large, community-based Korean cohort that was observed over 10 years.Patients and methods: A total of 4211 non-obese adults without diabetes aged 40– 69 years were selected from the Korean Genome and Epidemiology Study. The participants were divided into four groups according to WBC count quartiles. We prospectively assessed the hazard ratios (HRs) with 95% confidence intervals (CIs) for incident T2DM, based on the American Diabetes Association criteria, using multivariate Cox proportional hazards regression models over 10 years after the baseline survey.Results: During the follow-up period, 592 (14.1%) participants had newly developed T2DM. The higher quartile of WBC count groups showed significantly higher cumulative T2DM incidence over 10 years after the baseline survey (log-rank test, P < 0.001). Compared with the HRs for individuals in the referent lowest quartile, the HR (95% CI) for incident T2DM in individuals in the highest quartile was 1.55 (1.10– 2.18) after adjusting for confounding variables.Conclusion: A higher WBC count predicts future incident T2DM among community-dwelling non-obese Korean adults. This study suggests that WBC count could facilitate the prediction of non-obese individuals susceptible to T2DM.Keywords: white blood cell count, type 2 diabetes mellitus, chronic low-grade inflammation, non-obese adults
format	article
author	Park JM Lee HS Park JY Jung DH Lee JW
author_facet	Park JM Lee HS Park JY Jung DH Lee JW
author_sort	Park JM
title	White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
title_short	White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
title_full	White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
title_fullStr	White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
title_full_unstemmed	White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
title_sort	white blood cell count as a predictor of incident type 2 diabetes mellitus among non-obese adults: a longitudinal 10-year analysis of the korean genome and epidemiology study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/daca50f6665f489b8d6e120ffe7a6f52
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White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study

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