Role of Partial Splenectomy in Hematologic Childhood Disorders

The spleen is a secondary lymphoid organ that belongs to the reticular-endothelial system, directly connected to blood circulation. The spleen is greatly involved in the immune response, especially against capsulated bacteria. Splenectomy plays a fundamental role in the treatment of numerous pediatr...

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Autores principales:	Giorgio Attina’, Silvia Triarico, Alberto Romano, Palma Maurizi, Stefano Mastrangelo, Antonio Ruggiero
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	partial splenectomy children prophylaxis sepsis hematologic disorders vaccinations Medicine R
Acceso en línea:	https://doaj.org/article/dacbdce4c9e64db3b85fd9cfb253d713
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spelling	oai:doaj.org-article:dacbdce4c9e64db3b85fd9cfb253d7132021-11-25T18:38:15ZRole of Partial Splenectomy in Hematologic Childhood Disorders10.3390/pathogens101114362076-0817https://doaj.org/article/dacbdce4c9e64db3b85fd9cfb253d7132021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1436https://doaj.org/toc/2076-0817The spleen is a secondary lymphoid organ that belongs to the reticular-endothelial system, directly connected to blood circulation. The spleen is greatly involved in the immune response, especially against capsulated bacteria. Splenectomy plays a fundamental role in the treatment of numerous pediatric hematologic disorders. Taking into account all the possible complications (especially infections) linked to this procedure, alternatives to total splenectomy have been sought. Partial splenectomy has been proposed as a treatment that allows the reduction of infectious risk. This approach has proven safe and feasible in most patients, but multicentric and prospective studies are necessary to more accurately define the indications for performing partial splenectomy. However, vaccinations and antibiotic prophylaxis remain fundamental for preventing serious infections, even in the case of partial splenectomy. We review anatomical and functional properties of the spleen, with a focus on medical or surgical indications to splenectomy, aiming to give practical educational information to patients and their families after splenectomy. Furthermore, we discuss the feasibility of partial splenectomy in children with hematologic diseases who require splenectomy.Giorgio Attina’Silvia TriaricoAlberto RomanoPalma MauriziStefano MastrangeloAntonio RuggieroMDPI AGarticlepartial splenectomychildrenprophylaxissepsishematologic disordersvaccinationsMedicineRENPathogens, Vol 10, Iss 1436, p 1436 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	partial splenectomy children prophylaxis sepsis hematologic disorders vaccinations Medicine R
spellingShingle	partial splenectomy children prophylaxis sepsis hematologic disorders vaccinations Medicine R Giorgio Attina’ Silvia Triarico Alberto Romano Palma Maurizi Stefano Mastrangelo Antonio Ruggiero Role of Partial Splenectomy in Hematologic Childhood Disorders
description	The spleen is a secondary lymphoid organ that belongs to the reticular-endothelial system, directly connected to blood circulation. The spleen is greatly involved in the immune response, especially against capsulated bacteria. Splenectomy plays a fundamental role in the treatment of numerous pediatric hematologic disorders. Taking into account all the possible complications (especially infections) linked to this procedure, alternatives to total splenectomy have been sought. Partial splenectomy has been proposed as a treatment that allows the reduction of infectious risk. This approach has proven safe and feasible in most patients, but multicentric and prospective studies are necessary to more accurately define the indications for performing partial splenectomy. However, vaccinations and antibiotic prophylaxis remain fundamental for preventing serious infections, even in the case of partial splenectomy. We review anatomical and functional properties of the spleen, with a focus on medical or surgical indications to splenectomy, aiming to give practical educational information to patients and their families after splenectomy. Furthermore, we discuss the feasibility of partial splenectomy in children with hematologic diseases who require splenectomy.
format	article
author	Giorgio Attina’ Silvia Triarico Alberto Romano Palma Maurizi Stefano Mastrangelo Antonio Ruggiero
author_facet	Giorgio Attina’ Silvia Triarico Alberto Romano Palma Maurizi Stefano Mastrangelo Antonio Ruggiero
author_sort	Giorgio Attina’
title	Role of Partial Splenectomy in Hematologic Childhood Disorders
title_short	Role of Partial Splenectomy in Hematologic Childhood Disorders
title_full	Role of Partial Splenectomy in Hematologic Childhood Disorders
title_fullStr	Role of Partial Splenectomy in Hematologic Childhood Disorders
title_full_unstemmed	Role of Partial Splenectomy in Hematologic Childhood Disorders
title_sort	role of partial splenectomy in hematologic childhood disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dacbdce4c9e64db3b85fd9cfb253d713
work_keys_str_mv	AT giorgioattina roleofpartialsplenectomyinhematologicchildhooddisorders AT silviatriarico roleofpartialsplenectomyinhematologicchildhooddisorders AT albertoromano roleofpartialsplenectomyinhematologicchildhooddisorders AT palmamaurizi roleofpartialsplenectomyinhematologicchildhooddisorders AT stefanomastrangelo roleofpartialsplenectomyinhematologicchildhooddisorders AT antonioruggiero roleofpartialsplenectomyinhematologicchildhooddisorders
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Role of Partial Splenectomy in Hematologic Childhood Disorders

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