Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults

Mitochondrial dysfunction occurs in Parkinson's disease, although the underlying mechanisms are unclear. Here, the authors find necdin works to stabilise the mitochondrial regulator PGC-1α, and that overexpression of necdin protects against MPTP-mediated neurodegeneration both in vitro and in v...

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Autores principales:	Koichi Hasegawa, Toru Yasuda, Chinatsu Shiraishi, Kazushiro Fujiwara, Serge Przedborski, Hideki Mochizuki, Kazuaki Yoshikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dacc20ca8cd8457c8e9889ba9c258e86
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spelling	oai:doaj.org-article:dacc20ca8cd8457c8e9889ba9c258e862021-12-02T16:50:15ZPromotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults10.1038/ncomms109432041-1723https://doaj.org/article/dacc20ca8cd8457c8e9889ba9c258e862016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10943https://doaj.org/toc/2041-1723Mitochondrial dysfunction occurs in Parkinson's disease, although the underlying mechanisms are unclear. Here, the authors find necdin works to stabilise the mitochondrial regulator PGC-1α, and that overexpression of necdin protects against MPTP-mediated neurodegeneration both in vitro and in vivo.Koichi HasegawaToru YasudaChinatsu ShiraishiKazushiro FujiwaraSerge PrzedborskiHideki MochizukiKazuaki YoshikawaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Koichi Hasegawa Toru Yasuda Chinatsu Shiraishi Kazushiro Fujiwara Serge Przedborski Hideki Mochizuki Kazuaki Yoshikawa Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
description	Mitochondrial dysfunction occurs in Parkinson's disease, although the underlying mechanisms are unclear. Here, the authors find necdin works to stabilise the mitochondrial regulator PGC-1α, and that overexpression of necdin protects against MPTP-mediated neurodegeneration both in vitro and in vivo.
format	article
author	Koichi Hasegawa Toru Yasuda Chinatsu Shiraishi Kazushiro Fujiwara Serge Przedborski Hideki Mochizuki Kazuaki Yoshikawa
author_facet	Koichi Hasegawa Toru Yasuda Chinatsu Shiraishi Kazushiro Fujiwara Serge Przedborski Hideki Mochizuki Kazuaki Yoshikawa
author_sort	Koichi Hasegawa
title	Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
title_short	Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
title_full	Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
title_fullStr	Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
title_full_unstemmed	Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
title_sort	promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dacc20ca8cd8457c8e9889ba9c258e86
work_keys_str_mv	AT koichihasegawa promotionofmitochondrialbiogenesisbynecdinprotectsneuronsagainstmitochondrialinsults AT toruyasuda promotionofmitochondrialbiogenesisbynecdinprotectsneuronsagainstmitochondrialinsults AT chinatsushiraishi promotionofmitochondrialbiogenesisbynecdinprotectsneuronsagainstmitochondrialinsults AT kazushirofujiwara promotionofmitochondrialbiogenesisbynecdinprotectsneuronsagainstmitochondrialinsults AT sergeprzedborski promotionofmitochondrialbiogenesisbynecdinprotectsneuronsagainstmitochondrialinsults AT hidekimochizuki promotionofmitochondrialbiogenesisbynecdinprotectsneuronsagainstmitochondrialinsults AT kazuakiyoshikawa promotionofmitochondrialbiogenesisbynecdinprotectsneuronsagainstmitochondrialinsults
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Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults

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