Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults

Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults

Mitochondrial dysfunction occurs in Parkinson's disease, although the underlying mechanisms are unclear. Here, the authors find necdin works to stabilise the mitochondrial regulator PGC-1α, and that overexpression of necdin protects against MPTP-mediated neurodegeneration both in vitro and in v...

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Autores principales: Koichi Hasegawa, Toru Yasuda, Chinatsu Shiraishi, Kazushiro Fujiwara, Serge Przedborski, Hideki Mochizuki, Kazuaki Yoshikawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/dacc20ca8cd8457c8e9889ba9c258e86
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