Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine

Abstract Depression and anxiety, two of the most common mental health disorders, share common symptoms and treatments. Most pharmacological agents available to treat these disorders target monoamine systems. Currently, finding the most effective treatment for an individual is a process of trial and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elizabeth A. Pekarskaya, Emma S. Holt, Jay A. Gingrich, Mark S. Ansorge, Jonathan A. Javitch, Sarah E. Canetta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dacd9ec969a649caa396d38a5bf9a485
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dacd9ec969a649caa396d38a5bf9a485
record_format	dspace
spelling	oai:doaj.org-article:dacd9ec969a649caa396d38a5bf9a4852021-11-28T12:18:18ZTianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine10.1038/s41598-021-02074-92045-2322https://doaj.org/article/dacd9ec969a649caa396d38a5bf9a4852021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02074-9https://doaj.org/toc/2045-2322Abstract Depression and anxiety, two of the most common mental health disorders, share common symptoms and treatments. Most pharmacological agents available to treat these disorders target monoamine systems. Currently, finding the most effective treatment for an individual is a process of trial and error. To better understand how disease etiology may predict treatment response, we studied mice exposed developmentally to the selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX). These mice show the murine equivalent of anxiety- and depression-like symptoms in adulthood and here we report that these mice are also behaviorally resistant to the antidepressant-like effects of adult SSRI administration. We investigated whether tianeptine (TIA), which exerts its therapeutic effects through agonism of the mu-opioid receptor instead of targeting monoaminergic systems, would be more effective in this model. We found that C57BL/6J pups exposed to FLX from postnatal day 2 to 11 (PNFLX, the mouse equivalent in terms of brain development to the human third trimester) showed increased avoidant behaviors as adults that failed to improve, or were even exacerbated, by chronic SSRI treatment. By contrast, avoidant behaviors in these same mice were drastically improved following chronic treatment with TIA. Overall, this demonstrates that TIA may be a promising alternative treatment for patients that fail to respond to typical antidepressants, especially in patients whose serotonergic system has been altered by in utero exposure to SSRIs.Elizabeth A. PekarskayaEmma S. HoltJay A. GingrichMark S. AnsorgeJonathan A. JavitchSarah E. CanettaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elizabeth A. Pekarskaya Emma S. Holt Jay A. Gingrich Mark S. Ansorge Jonathan A. Javitch Sarah E. Canetta Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine
description	Abstract Depression and anxiety, two of the most common mental health disorders, share common symptoms and treatments. Most pharmacological agents available to treat these disorders target monoamine systems. Currently, finding the most effective treatment for an individual is a process of trial and error. To better understand how disease etiology may predict treatment response, we studied mice exposed developmentally to the selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX). These mice show the murine equivalent of anxiety- and depression-like symptoms in adulthood and here we report that these mice are also behaviorally resistant to the antidepressant-like effects of adult SSRI administration. We investigated whether tianeptine (TIA), which exerts its therapeutic effects through agonism of the mu-opioid receptor instead of targeting monoaminergic systems, would be more effective in this model. We found that C57BL/6J pups exposed to FLX from postnatal day 2 to 11 (PNFLX, the mouse equivalent in terms of brain development to the human third trimester) showed increased avoidant behaviors as adults that failed to improve, or were even exacerbated, by chronic SSRI treatment. By contrast, avoidant behaviors in these same mice were drastically improved following chronic treatment with TIA. Overall, this demonstrates that TIA may be a promising alternative treatment for patients that fail to respond to typical antidepressants, especially in patients whose serotonergic system has been altered by in utero exposure to SSRIs.
format	article
author	Elizabeth A. Pekarskaya Emma S. Holt Jay A. Gingrich Mark S. Ansorge Jonathan A. Javitch Sarah E. Canetta
author_facet	Elizabeth A. Pekarskaya Emma S. Holt Jay A. Gingrich Mark S. Ansorge Jonathan A. Javitch Sarah E. Canetta
author_sort	Elizabeth A. Pekarskaya
title	Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine
title_short	Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine
title_full	Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine
title_fullStr	Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine
title_full_unstemmed	Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine
title_sort	tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dacd9ec969a649caa396d38a5bf9a485
work_keys_str_mv	AT elizabethapekarskaya tianeptinebutnotfluoxetinedecreasesavoidantbehaviorinamousemodelofearlydevelopmentalexposuretofluoxetine AT emmasholt tianeptinebutnotfluoxetinedecreasesavoidantbehaviorinamousemodelofearlydevelopmentalexposuretofluoxetine AT jayagingrich tianeptinebutnotfluoxetinedecreasesavoidantbehaviorinamousemodelofearlydevelopmentalexposuretofluoxetine AT marksansorge tianeptinebutnotfluoxetinedecreasesavoidantbehaviorinamousemodelofearlydevelopmentalexposuretofluoxetine AT jonathanajavitch tianeptinebutnotfluoxetinedecreasesavoidantbehaviorinamousemodelofearlydevelopmentalexposuretofluoxetine AT sarahecanetta tianeptinebutnotfluoxetinedecreasesavoidantbehaviorinamousemodelofearlydevelopmentalexposuretofluoxetine
_version_	1718408106863493120

Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine

Ejemplares similares