Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

At inflammatory sites, ectopic lymphoid-like structures (ELS) can be induced through the function of chemokine CXCL13 produced by CD4+ T cells. Here the authors show that a transcription factor, Sox4, induces the expression of CXCL13 in CD4 T cells in vitro, and is associated with ELS formation in p...

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Main Authors: Hiroyuki Yoshitomi, Shio Kobayashi, Aya Miyagawa-Hayashino, Akinori Okahata, Kohei Doi, Kohei Nishitani, Koichi Murata, Hiromu Ito, Tatsuaki Tsuruyama, Hironori Haga, Shuichi Matsuda, Junya Toguchida
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/dacfc17c85c14dde94e961201bf3b135
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Summary:At inflammatory sites, ectopic lymphoid-like structures (ELS) can be induced through the function of chemokine CXCL13 produced by CD4+ T cells. Here the authors show that a transcription factor, Sox4, induces the expression of CXCL13 in CD4 T cells in vitro, and is associated with ELS formation in patients with rheumatoid arthritis.

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