Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

At inflammatory sites, ectopic lymphoid-like structures (ELS) can be induced through the function of chemokine CXCL13 produced by CD4+ T cells. Here the authors show that a transcription factor, Sox4, induces the expression of CXCL13 in CD4 T cells in vitro, and is associated with ELS formation in p...

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Autores principales:	Hiroyuki Yoshitomi, Shio Kobayashi, Aya Miyagawa-Hayashino, Akinori Okahata, Kohei Doi, Kohei Nishitani, Koichi Murata, Hiromu Ito, Tatsuaki Tsuruyama, Hironori Haga, Shuichi Matsuda, Junya Toguchida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dacfc17c85c14dde94e961201bf3b135
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spelling	oai:doaj.org-article:dacfc17c85c14dde94e961201bf3b1352021-12-02T14:39:45ZHuman Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments10.1038/s41467-018-06187-02041-1723https://doaj.org/article/dacfc17c85c14dde94e961201bf3b1352018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06187-0https://doaj.org/toc/2041-1723At inflammatory sites, ectopic lymphoid-like structures (ELS) can be induced through the function of chemokine CXCL13 produced by CD4+ T cells. Here the authors show that a transcription factor, Sox4, induces the expression of CXCL13 in CD4 T cells in vitro, and is associated with ELS formation in patients with rheumatoid arthritis.Hiroyuki YoshitomiShio KobayashiAya Miyagawa-HayashinoAkinori OkahataKohei DoiKohei NishitaniKoichi MurataHiromu ItoTatsuaki TsuruyamaHironori HagaShuichi MatsudaJunya ToguchidaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroyuki Yoshitomi Shio Kobayashi Aya Miyagawa-Hayashino Akinori Okahata Kohei Doi Kohei Nishitani Koichi Murata Hiromu Ito Tatsuaki Tsuruyama Hironori Haga Shuichi Matsuda Junya Toguchida Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments
description	At inflammatory sites, ectopic lymphoid-like structures (ELS) can be induced through the function of chemokine CXCL13 produced by CD4+ T cells. Here the authors show that a transcription factor, Sox4, induces the expression of CXCL13 in CD4 T cells in vitro, and is associated with ELS formation in patients with rheumatoid arthritis.
format	article
author	Hiroyuki Yoshitomi Shio Kobayashi Aya Miyagawa-Hayashino Akinori Okahata Kohei Doi Kohei Nishitani Koichi Murata Hiromu Ito Tatsuaki Tsuruyama Hironori Haga Shuichi Matsuda Junya Toguchida
author_facet	Hiroyuki Yoshitomi Shio Kobayashi Aya Miyagawa-Hayashino Akinori Okahata Kohei Doi Kohei Nishitani Koichi Murata Hiromu Ito Tatsuaki Tsuruyama Hironori Haga Shuichi Matsuda Junya Toguchida
author_sort	Hiroyuki Yoshitomi
title	Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments
title_short	Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments
title_full	Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments
title_fullStr	Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments
title_full_unstemmed	Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments
title_sort	human sox4 facilitates the development of cxcl13-producing helper t cells in inflammatory environments
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dacfc17c85c14dde94e961201bf3b135
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Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

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