A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics

A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics

The GABAergic and peptidergic neuron RIS mediates sleep in Caenorhabditis elegans. The authors demonstrated here that RIS also functions as a locomotion stop neuron. Its optogenetic stimulation caused acute and persistent inhibition of locomotion, and brief intrinsic RIS activity preceded slowing.

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Detalles Bibliográficos
Autores principales: Wagner Steuer Costa, Petrus Van der Auwera, Caspar Glock, Jana F. Liewald, Maximilian Bach, Christina Schüler, Sebastian Wabnig, Alexandra Oranth, Florentin Masurat, Henrik Bringmann, Liliane Schoofs, Ernst H. K. Stelzer, Sabine C. Fischer, Alexander Gottschalk
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/dadadbc0392146fd8d67f3ec1c6b32b4
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Descripción
Sumario:The GABAergic and peptidergic neuron RIS mediates sleep in Caenorhabditis elegans. The authors demonstrated here that RIS also functions as a locomotion stop neuron. Its optogenetic stimulation caused acute and persistent inhibition of locomotion, and brief intrinsic RIS activity preceded slowing.

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