A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics

The GABAergic and peptidergic neuron RIS mediates sleep in Caenorhabditis elegans. The authors demonstrated here that RIS also functions as a locomotion stop neuron. Its optogenetic stimulation caused acute and persistent inhibition of locomotion, and brief intrinsic RIS activity preceded slowing.

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Autores principales:	Wagner Steuer Costa, Petrus Van der Auwera, Caspar Glock, Jana F. Liewald, Maximilian Bach, Christina Schüler, Sebastian Wabnig, Alexandra Oranth, Florentin Masurat, Henrik Bringmann, Liliane Schoofs, Ernst H. K. Stelzer, Sabine C. Fischer, Alexander Gottschalk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dadadbc0392146fd8d67f3ec1c6b32b4
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spelling	oai:doaj.org-article:dadadbc0392146fd8d67f3ec1c6b32b42021-12-02T16:57:24ZA GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics10.1038/s41467-019-12098-52041-1723https://doaj.org/article/dadadbc0392146fd8d67f3ec1c6b32b42019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12098-5https://doaj.org/toc/2041-1723The GABAergic and peptidergic neuron RIS mediates sleep in Caenorhabditis elegans. The authors demonstrated here that RIS also functions as a locomotion stop neuron. Its optogenetic stimulation caused acute and persistent inhibition of locomotion, and brief intrinsic RIS activity preceded slowing.Wagner Steuer CostaPetrus Van der AuweraCaspar GlockJana F. LiewaldMaximilian BachChristina SchülerSebastian WabnigAlexandra OranthFlorentin MasuratHenrik BringmannLiliane SchoofsErnst H. K. StelzerSabine C. FischerAlexander GottschalkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wagner Steuer Costa Petrus Van der Auwera Caspar Glock Jana F. Liewald Maximilian Bach Christina Schüler Sebastian Wabnig Alexandra Oranth Florentin Masurat Henrik Bringmann Liliane Schoofs Ernst H. K. Stelzer Sabine C. Fischer Alexander Gottschalk A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics
description	The GABAergic and peptidergic neuron RIS mediates sleep in Caenorhabditis elegans. The authors demonstrated here that RIS also functions as a locomotion stop neuron. Its optogenetic stimulation caused acute and persistent inhibition of locomotion, and brief intrinsic RIS activity preceded slowing.
format	article
author	Wagner Steuer Costa Petrus Van der Auwera Caspar Glock Jana F. Liewald Maximilian Bach Christina Schüler Sebastian Wabnig Alexandra Oranth Florentin Masurat Henrik Bringmann Liliane Schoofs Ernst H. K. Stelzer Sabine C. Fischer Alexander Gottschalk
author_facet	Wagner Steuer Costa Petrus Van der Auwera Caspar Glock Jana F. Liewald Maximilian Bach Christina Schüler Sebastian Wabnig Alexandra Oranth Florentin Masurat Henrik Bringmann Liliane Schoofs Ernst H. K. Stelzer Sabine C. Fischer Alexander Gottschalk
author_sort	Wagner Steuer Costa
title	A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics
title_short	A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics
title_full	A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics
title_fullStr	A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics
title_full_unstemmed	A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics
title_sort	gabaergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized ca2+ dynamics
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dadadbc0392146fd8d67f3ec1c6b32b4
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A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics

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