Separating microparticles by material and size using dielectrophoretic chromatography with frequency modulation

Abstract Separation of (biological) particles ( $$\ll {10}~{\upmu }\text {m}$$ ≪ 10 μ m ) according to size or other properties is an ongoing challenge in a variety of technical relevant fields. Dielectrophoresis is one method to separate particles according to a diversity of properties, and within...

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Autores principales:	Jasper Giesler, Laura Weirauch, Jorg Thöming, Michael Baune, Georg R. Pesch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dade81d2345e4503a758760c56b891d3
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spelling	oai:doaj.org-article:dade81d2345e4503a758760c56b891d32021-12-02T15:10:50ZSeparating microparticles by material and size using dielectrophoretic chromatography with frequency modulation10.1038/s41598-021-95404-w2045-2322https://doaj.org/article/dade81d2345e4503a758760c56b891d32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95404-whttps://doaj.org/toc/2045-2322Abstract Separation of (biological) particles ( $$\ll {10}~{\upmu }\text {m}$$ ≪ 10 μ m ) according to size or other properties is an ongoing challenge in a variety of technical relevant fields. Dielectrophoresis is one method to separate particles according to a diversity of properties, and within the last decades a pool of dielectrophoretic separation techniques has been developed. However, many of them either suffer selectivity or throughput. We use simulation and experiments to investigate retention mechanisms in a novel DEP scheme, namely, frequency-modulated DEP. Results from experiments and simulation show a good agreement for the separation of binary PS particles mixtures with respect to size and more importantly, for the challenging task of separating equally sized microparticles according to surface functionalization alone. The separation with respect to size was performed using 2 $${\upmu }$$ μ m and 3 $${\upmu }$$ μ m sized particles, whereas separation with respect to surface functionalization was performed with 2 $${\upmu }$$ μ m particles. The results from this study can be used to solve challenging separation tasks, for example to separate particles with distributed properties.Jasper GieslerLaura WeirauchJorg ThömingMichael BauneGeorg R. PeschNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jasper Giesler Laura Weirauch Jorg Thöming Michael Baune Georg R. Pesch Separating microparticles by material and size using dielectrophoretic chromatography with frequency modulation
description	Abstract Separation of (biological) particles ( $$\ll {10}~{\upmu }\text {m}$$ ≪ 10 μ m ) according to size or other properties is an ongoing challenge in a variety of technical relevant fields. Dielectrophoresis is one method to separate particles according to a diversity of properties, and within the last decades a pool of dielectrophoretic separation techniques has been developed. However, many of them either suffer selectivity or throughput. We use simulation and experiments to investigate retention mechanisms in a novel DEP scheme, namely, frequency-modulated DEP. Results from experiments and simulation show a good agreement for the separation of binary PS particles mixtures with respect to size and more importantly, for the challenging task of separating equally sized microparticles according to surface functionalization alone. The separation with respect to size was performed using 2 $${\upmu }$$ μ m and 3 $${\upmu }$$ μ m sized particles, whereas separation with respect to surface functionalization was performed with 2 $${\upmu }$$ μ m particles. The results from this study can be used to solve challenging separation tasks, for example to separate particles with distributed properties.
format	article
author	Jasper Giesler Laura Weirauch Jorg Thöming Michael Baune Georg R. Pesch
author_facet	Jasper Giesler Laura Weirauch Jorg Thöming Michael Baune Georg R. Pesch
author_sort	Jasper Giesler
title	Separating microparticles by material and size using dielectrophoretic chromatography with frequency modulation
title_short	Separating microparticles by material and size using dielectrophoretic chromatography with frequency modulation
title_full	Separating microparticles by material and size using dielectrophoretic chromatography with frequency modulation
title_fullStr	Separating microparticles by material and size using dielectrophoretic chromatography with frequency modulation
title_full_unstemmed	Separating microparticles by material and size using dielectrophoretic chromatography with frequency modulation
title_sort	separating microparticles by material and size using dielectrophoretic chromatography with frequency modulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dade81d2345e4503a758760c56b891d3
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_version_	1718387723043078144

Separating microparticles by material and size using dielectrophoretic chromatography with frequency modulation

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