Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice

Abstract Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-strand breaks h...

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Autores principales:	Zhonghe Ke, Denis Firsanov, Brianna Spencer, Andrei Seluanov, Vera Gorbunova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/dae01c77a29c49f58149d7b030add56c
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spelling	oai:doaj.org-article:dae01c77a29c49f58149d7b030add56c2021-12-02T16:27:49ZShort-term calorie restriction enhances DNA repair by non-homologous end joining in mice10.1038/s41514-020-00047-22056-3973https://doaj.org/article/dae01c77a29c49f58149d7b030add56c2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41514-020-00047-2https://doaj.org/toc/2056-3973Abstract Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-strand breaks has not been examined in in vivo system. Here we utilize non-homologous end joining (NHEJ) reporter mice to show that short-term CR strongly enhances DNA repair by NHEJ, which is associated with elevated levels of DNA-PK and SIRT6.Zhonghe KeDenis FirsanovBrianna SpencerAndrei SeluanovVera GorbunovaNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Zhonghe Ke Denis Firsanov Brianna Spencer Andrei Seluanov Vera Gorbunova Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
description	Abstract Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-strand breaks has not been examined in in vivo system. Here we utilize non-homologous end joining (NHEJ) reporter mice to show that short-term CR strongly enhances DNA repair by NHEJ, which is associated with elevated levels of DNA-PK and SIRT6.
format	article
author	Zhonghe Ke Denis Firsanov Brianna Spencer Andrei Seluanov Vera Gorbunova
author_facet	Zhonghe Ke Denis Firsanov Brianna Spencer Andrei Seluanov Vera Gorbunova
author_sort	Zhonghe Ke
title	Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_short	Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_full	Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_fullStr	Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_full_unstemmed	Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
title_sort	short-term calorie restriction enhances dna repair by non-homologous end joining in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dae01c77a29c49f58149d7b030add56c
work_keys_str_mv	AT zhongheke shorttermcalorierestrictionenhancesdnarepairbynonhomologousendjoininginmice AT denisfirsanov shorttermcalorierestrictionenhancesdnarepairbynonhomologousendjoininginmice AT briannaspencer shorttermcalorierestrictionenhancesdnarepairbynonhomologousendjoininginmice AT andreiseluanov shorttermcalorierestrictionenhancesdnarepairbynonhomologousendjoininginmice AT veragorbunova shorttermcalorierestrictionenhancesdnarepairbynonhomologousendjoininginmice
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Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice

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