Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice
BACKGROUND AND OBJECTIVE: Busulfan is a chemotherapy drug that has side effects such as hepatic and renal injury. Pistacia atlantica from the family Anacardiaceae has a potent antioxidant agent due to phenolic compounds. The purpose of this study was to investigate the effects of Pistacia atlantica...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN FA |
| Publicado: |
Babol University of Medical Sciences
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/dae036ebd58344d89af114e17f493cbb |
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| Sumario: | BACKGROUND AND OBJECTIVE: Busulfan is a chemotherapy drug that has side effects such as hepatic and renal injury. Pistacia atlantica from the family Anacardiaceae has a potent antioxidant agent due to phenolic compounds. The purpose of this study was to investigate the effects of Pistacia atlantica on histopathology and liver and kidney function indicators in busulfan-induced liver and kidney injuries in adult mice.
METHODS: A total of 28 BALB/c mice were randomly divided into four groups (control, busulfan, bene and bene+busulfan). The busulfan group received 10 mg/kg busulfan as a single dose and intraperitoneally. The bene group received plate containing 10% of bene for 35 days. The bene+busulfan group received 10 mg/kg busulfan+10% bene. Then, liver enzymes alanine amino transferase, aspartate amino transferase, urea, creatinine and histopathology of liver and kidney investigated.
FINDINGS: The mean urea (P= 0.009) and creatinine level (P= 0.02) in the busulfan group was 55.2±4.23 and 0.8±0.11 mg/dl that it was significantly higher than the bene + busulfan. A significant decrease in ALT level in the bene + busulfan group compared to the busulfan treated group (P= 0.03). In the bene treated group steatosis, necrosis and fibrosis in the liver parenchyma and glomerular sclerosis, inflammation and tubular atrophy in kidney tissue, was not observed.
CONCLUSION: The results of present study indicated that administration of 10% bene for 35 days improved histopathology of kidney and liver as well as functional index of liver and kidney after renal-liver injury. |
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