Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice

BACKGROUND AND OBJECTIVE: Busulfan is a chemotherapy drug that has side effects such as hepatic and renal injury. Pistacia atlantica from the family Anacardiaceae has a potent antioxidant agent due to phenolic compounds. The purpose of this study was to investigate the effects of Pistacia atlantica...

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Autores principales:	H Norasteh, Sh Mohammadi, M Nikravesh, Sh Taraz Jamshidi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	pistacia atlantica wild pistacia mouse liver kidney busulfan. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dae036ebd58344d89af114e17f493cbb
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spelling	oai:doaj.org-article:dae036ebd58344d89af114e17f493cbb2021-11-09T10:15:54ZProtective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice1561-41072251-7170https://doaj.org/article/dae036ebd58344d89af114e17f493cbb2020-03-01T00:00:00Zhttp://jbums.org/article-1-8351-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Busulfan is a chemotherapy drug that has side effects such as hepatic and renal injury. Pistacia atlantica from the family Anacardiaceae has a potent antioxidant agent due to phenolic compounds. The purpose of this study was to investigate the effects of Pistacia atlantica on histopathology and liver and kidney function indicators in busulfan-induced liver and kidney injuries in adult mice. METHODS: A total of 28 BALB/c mice were randomly divided into four groups (control, busulfan, bene and bene+busulfan). The busulfan group received 10 mg/kg busulfan as a single dose and intraperitoneally. The bene group received plate containing 10% of bene for 35 days. The bene+busulfan group received 10 mg/kg busulfan+10% bene. Then, liver enzymes alanine amino transferase, aspartate amino transferase, urea, creatinine and histopathology of liver and kidney investigated. FINDINGS: The mean urea (P= 0.009) and creatinine level (P= 0.02) in the busulfan group was 55.2±4.23 and 0.8±0.11 mg/dl that it was significantly higher than the bene + busulfan. A significant decrease in ALT level in the bene + busulfan group compared to the busulfan treated group (P= 0.03). In the bene treated group steatosis, necrosis and fibrosis in the liver parenchyma and glomerular sclerosis, inflammation and tubular atrophy in kidney tissue, was not observed. CONCLUSION: The results of present study indicated that administration of 10% bene for 35 days improved histopathology of kidney and liver as well as functional index of liver and kidney after renal-liver injury.H NorastehSh MohammadiM NikraveshSh Taraz JamshidiBabol University of Medical Sciencesarticlepistacia atlanticawild pistaciamouseliverkidneybusulfan.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 17-23 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	pistacia atlantica wild pistacia mouse liver kidney busulfan. Medicine R Medicine (General) R5-920
spellingShingle	pistacia atlantica wild pistacia mouse liver kidney busulfan. Medicine R Medicine (General) R5-920 H Norasteh Sh Mohammadi M Nikravesh Sh Taraz Jamshidi Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice
description	BACKGROUND AND OBJECTIVE: Busulfan is a chemotherapy drug that has side effects such as hepatic and renal injury. Pistacia atlantica from the family Anacardiaceae has a potent antioxidant agent due to phenolic compounds. The purpose of this study was to investigate the effects of Pistacia atlantica on histopathology and liver and kidney function indicators in busulfan-induced liver and kidney injuries in adult mice. METHODS: A total of 28 BALB/c mice were randomly divided into four groups (control, busulfan, bene and bene+busulfan). The busulfan group received 10 mg/kg busulfan as a single dose and intraperitoneally. The bene group received plate containing 10% of bene for 35 days. The bene+busulfan group received 10 mg/kg busulfan+10% bene. Then, liver enzymes alanine amino transferase, aspartate amino transferase, urea, creatinine and histopathology of liver and kidney investigated. FINDINGS: The mean urea (P= 0.009) and creatinine level (P= 0.02) in the busulfan group was 55.2±4.23 and 0.8±0.11 mg/dl that it was significantly higher than the bene + busulfan. A significant decrease in ALT level in the bene + busulfan group compared to the busulfan treated group (P= 0.03). In the bene treated group steatosis, necrosis and fibrosis in the liver parenchyma and glomerular sclerosis, inflammation and tubular atrophy in kidney tissue, was not observed. CONCLUSION: The results of present study indicated that administration of 10% bene for 35 days improved histopathology of kidney and liver as well as functional index of liver and kidney after renal-liver injury.
format	article
author	H Norasteh Sh Mohammadi M Nikravesh Sh Taraz Jamshidi
author_facet	H Norasteh Sh Mohammadi M Nikravesh Sh Taraz Jamshidi
author_sort	H Norasteh
title	Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice
title_short	Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice
title_full	Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice
title_fullStr	Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice
title_full_unstemmed	Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice
title_sort	protective effect of bene (pistacia atlantica) on busulfan-induced renal-liver injury in laboratory mice
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/dae036ebd58344d89af114e17f493cbb
work_keys_str_mv	AT hnorasteh protectiveeffectofbenepistaciaatlanticaonbusulfaninducedrenalliverinjuryinlaboratorymice AT shmohammadi protectiveeffectofbenepistaciaatlanticaonbusulfaninducedrenalliverinjuryinlaboratorymice AT mnikravesh protectiveeffectofbenepistaciaatlanticaonbusulfaninducedrenalliverinjuryinlaboratorymice AT shtarazjamshidi protectiveeffectofbenepistaciaatlanticaonbusulfaninducedrenalliverinjuryinlaboratorymice
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Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice

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