Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges

Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuva...

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Autores principales:	Zhi Zhu, Ying-Bo Gong, Hui-Mian Xu
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Gastric cancer Neoadjuvant therapy Chemotherapy Radiotherapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dae57b02a2fb4e8a99c0555b5a042a44
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spelling	oai:doaj.org-article:dae57b02a2fb4e8a99c0555b5a042a442021-12-02T13:36:25ZNeoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges2095-882X10.1016/j.cdtm.2020.03.004https://doaj.org/article/dae57b02a2fb4e8a99c0555b5a042a442020-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X20300359https://doaj.org/toc/2095-882XGastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuvant approaches confer a significant survival advantage for resectable locally advanced gastric cancer. The specific advantages of chemoradiotherapy compared with chemotherapy have not been clarified; optimal regimens and cycles, particularly in the preoperative setting, should be studied further; and trials aimed at determining the role of targeted and immunological therapies should be conducted.Zhi ZhuYing-Bo GongHui-Mian XuKeAi Communications Co., Ltd.articleGastric cancerNeoadjuvant therapyChemotherapyRadiotherapyMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 6, Iss 3, Pp 147-157 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gastric cancer Neoadjuvant therapy Chemotherapy Radiotherapy Medicine (General) R5-920
spellingShingle	Gastric cancer Neoadjuvant therapy Chemotherapy Radiotherapy Medicine (General) R5-920 Zhi Zhu Ying-Bo Gong Hui-Mian Xu Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges
description	Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuvant approaches confer a significant survival advantage for resectable locally advanced gastric cancer. The specific advantages of chemoradiotherapy compared with chemotherapy have not been clarified; optimal regimens and cycles, particularly in the preoperative setting, should be studied further; and trials aimed at determining the role of targeted and immunological therapies should be conducted.
format	article
author	Zhi Zhu Ying-Bo Gong Hui-Mian Xu
author_facet	Zhi Zhu Ying-Bo Gong Hui-Mian Xu
author_sort	Zhi Zhu
title	Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges
title_short	Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges
title_full	Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges
title_fullStr	Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges
title_full_unstemmed	Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges
title_sort	neoadjuvant therapy strategies for advanced gastric cancer: current innovations and future challenges
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/dae57b02a2fb4e8a99c0555b5a042a44
work_keys_str_mv	AT zhizhu neoadjuvanttherapystrategiesforadvancedgastriccancercurrentinnovationsandfuturechallenges AT yingbogong neoadjuvanttherapystrategiesforadvancedgastriccancercurrentinnovationsandfuturechallenges AT huimianxu neoadjuvanttherapystrategiesforadvancedgastriccancercurrentinnovationsandfuturechallenges
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Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges

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