Involvement of N-methylpurine DNA glycosylase in resistance to temozolomide in patient-derived glioma cells

Abstract Chemotherapy for high-grade astrocytic tumors is mainly based on the use of temozolomide (TMZ), whose efficacy is limited by resistance mechanisms. Despite many investigations pointing to O6-methylguanine-DNA-methyltransferase (MGMT) as being responsible for tumor chemo-resistance, its expr...

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Bibliographic Details
Main Authors: Gemma Serrano-Heras, Beatriz Castro-Robles, Carlos M. Romero-Sánchez, Blanca Carrión, Rosa Barbella-Aponte, Hernán Sandoval, Tomás Segura
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
R
Q
Online Access:https://doaj.org/article/dae88f83974f4fc9a5df3c7c493518eb
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