Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life

Coacervate droplets (CDs) are a model for protocells formed by liquid-liquid phase separation (LLPS), but protocell models able to proliferate remain undeveloped. Here, the authors report a proliferating peptide-based CD using synthesised amino acid thioesters as monomers, which could concentrate RN...

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Main Authors:	Muneyuki Matsuo, Kensuke Kurihara
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/dae9d84c4b57423fb73dad6a309a93dd
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id	oai:doaj.org-article:dae9d84c4b57423fb73dad6a309a93dd
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spelling	oai:doaj.org-article:dae9d84c4b57423fb73dad6a309a93dd2021-12-02T18:14:23ZProliferating coacervate droplets as the missing link between chemistry and biology in the origins of life10.1038/s41467-021-25530-62041-1723https://doaj.org/article/dae9d84c4b57423fb73dad6a309a93dd2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25530-6https://doaj.org/toc/2041-1723Coacervate droplets (CDs) are a model for protocells formed by liquid-liquid phase separation (LLPS), but protocell models able to proliferate remain undeveloped. Here, the authors report a proliferating peptide-based CD using synthesised amino acid thioesters as monomers, which could concentrate RNA and lipids, enabling RNA to protect the droplet from dissolution by lipids.Muneyuki MatsuoKensuke KuriharaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Muneyuki Matsuo Kensuke Kurihara Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
description	Coacervate droplets (CDs) are a model for protocells formed by liquid-liquid phase separation (LLPS), but protocell models able to proliferate remain undeveloped. Here, the authors report a proliferating peptide-based CD using synthesised amino acid thioesters as monomers, which could concentrate RNA and lipids, enabling RNA to protect the droplet from dissolution by lipids.
format	article
author	Muneyuki Matsuo Kensuke Kurihara
author_facet	Muneyuki Matsuo Kensuke Kurihara
author_sort	Muneyuki Matsuo
title	Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_short	Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_full	Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_fullStr	Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_full_unstemmed	Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_sort	proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dae9d84c4b57423fb73dad6a309a93dd
work_keys_str_mv	AT muneyukimatsuo proliferatingcoacervatedropletsasthemissinglinkbetweenchemistryandbiologyintheoriginsoflife AT kensukekurihara proliferatingcoacervatedropletsasthemissinglinkbetweenchemistryandbiologyintheoriginsoflife
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Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life

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