Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that are associated with relevant endophenotypes.

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Autores principales:	Xiaopu Zhou, Yu Chen, Kin Y. Mok, Timothy C. Y. Kwok, Vincent C. T. Mok, Qihao Guo, Fanny C. Ip, Yuewen Chen, Nandita Mullapudi, Alzheimer’s Disease Neuroimaging Initiative, Paola Giusti-Rodríguez, Patrick F. Sullivan, John Hardy, Amy K. Y. Fu, Yun Li, Nancy Y. Ip
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/daea0c2091424966946bd2ca4738d8a4
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spelling	oai:doaj.org-article:daea0c2091424966946bd2ca4738d8a42021-12-02T16:57:06ZNon-coding variability at the APOE locus contributes to the Alzheimer’s risk10.1038/s41467-019-10945-z2041-1723https://doaj.org/article/daea0c2091424966946bd2ca4738d8a42019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10945-zhttps://doaj.org/toc/2041-1723Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that are associated with relevant endophenotypes.Xiaopu ZhouYu ChenKin Y. MokTimothy C. Y. KwokVincent C. T. MokQihao GuoFanny C. IpYuewen ChenNandita MullapudiAlzheimer’s Disease Neuroimaging InitiativePaola Giusti-RodríguezPatrick F. SullivanJohn HardyAmy K. Y. FuYun LiNancy Y. IpNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaopu Zhou Yu Chen Kin Y. Mok Timothy C. Y. Kwok Vincent C. T. Mok Qihao Guo Fanny C. Ip Yuewen Chen Nandita Mullapudi Alzheimer’s Disease Neuroimaging Initiative Paola Giusti-Rodríguez Patrick F. Sullivan John Hardy Amy K. Y. Fu Yun Li Nancy Y. Ip Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
description	Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that are associated with relevant endophenotypes.
format	article
author	Xiaopu Zhou Yu Chen Kin Y. Mok Timothy C. Y. Kwok Vincent C. T. Mok Qihao Guo Fanny C. Ip Yuewen Chen Nandita Mullapudi Alzheimer’s Disease Neuroimaging Initiative Paola Giusti-Rodríguez Patrick F. Sullivan John Hardy Amy K. Y. Fu Yun Li Nancy Y. Ip
author_facet	Xiaopu Zhou Yu Chen Kin Y. Mok Timothy C. Y. Kwok Vincent C. T. Mok Qihao Guo Fanny C. Ip Yuewen Chen Nandita Mullapudi Alzheimer’s Disease Neuroimaging Initiative Paola Giusti-Rodríguez Patrick F. Sullivan John Hardy Amy K. Y. Fu Yun Li Nancy Y. Ip
author_sort	Xiaopu Zhou
title	Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
title_short	Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
title_full	Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
title_fullStr	Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
title_full_unstemmed	Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
title_sort	non-coding variability at the apoe locus contributes to the alzheimer’s risk
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/daea0c2091424966946bd2ca4738d8a4
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Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

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