Virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case

Objectives. The relationship between the development of the number of malignant tumors in children and viruses is well known. The etiological role of the EpsteinBarr virus in the development of undifferentiated nasopharyngeal cancer (NPC) has been well studied. The effect of human papillomavirus (HP...

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Autores principales:	Tatiana V. Gorbunova, Elena Iu. Radtsig, Oleg A. Merkulov, Mikhail R. Bogomil’skii, Vladimir G. Poliakov
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2020
Materias:	human papillomavirus children oropharyngeal papillomatosis undifferentiated nasopharyngeal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/daeaf2ecfe6b4665bef4ac762c93bb6b
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spelling	oai:doaj.org-article:daeaf2ecfe6b4665bef4ac762c93bb6b2021-11-30T17:03:34ZVirus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case1815-14341815-144210.26442/18151434.2020.2.200119https://doaj.org/article/daeaf2ecfe6b4665bef4ac762c93bb6b2020-07-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/35197/23620https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Objectives. The relationship between the development of the number of malignant tumors in children and viruses is well known. The etiological role of the EpsteinBarr virus in the development of undifferentiated nasopharyngeal cancer (NPC) has been well studied. The effect of human papillomavirus (HPV) on the occurrence and development of NPC in children is not sufficiently understood. Aim. The description of the clinical case of the Epstein Barr virus and HPV infection in 16-year-old patient with the consistent development of NPC and oropharyngeal papillomatosis. Description of the clinical case. The clinical observation of the boy who was diagnosed with NPC. The full clinical effect in the form of reduction of the primary tumor and metastases in the lymph nodes of the neck was noted after chemo- and radiotherapy. 18 months after the cure according to the positron emission tomography, combined with computed tomography, with 18F-deoxyglucose we marked the accumulation of radiopharmaceuticals in the area of the left palatine and lingual tonsils. The examination revealed clinical signs of the soft palate papillomatosis. The resection of the soft palate was carried out. The morphological study confirmed squamous cell papilloma. HPV type 16 DNA was found in the papilloma. Conclusion. The accumulation of the information concerning childhood pharynx lesions caused by HPV would help to expand understanding of the most common types of the virus in the paediatric population. It would be possible to identify the groups of risk for the development of malignant tumors on the grounds of the detection HPV types of highly carcinogenic risk.Tatiana V. GorbunovaElena Iu. RadtsigOleg A. MerkulovMikhail R. Bogomil’skiiVladimir G. PoliakovIP Habib O.N.articlehuman papillomaviruschildrenoropharyngeal papillomatosisundifferentiated nasopharyngeal cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 22, Iss 2, Pp 137-141 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	human papillomavirus children oropharyngeal papillomatosis undifferentiated nasopharyngeal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	human papillomavirus children oropharyngeal papillomatosis undifferentiated nasopharyngeal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Tatiana V. Gorbunova Elena Iu. Radtsig Oleg A. Merkulov Mikhail R. Bogomil’skii Vladimir G. Poliakov Virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case
description	Objectives. The relationship between the development of the number of malignant tumors in children and viruses is well known. The etiological role of the EpsteinBarr virus in the development of undifferentiated nasopharyngeal cancer (NPC) has been well studied. The effect of human papillomavirus (HPV) on the occurrence and development of NPC in children is not sufficiently understood. Aim. The description of the clinical case of the Epstein Barr virus and HPV infection in 16-year-old patient with the consistent development of NPC and oropharyngeal papillomatosis. Description of the clinical case. The clinical observation of the boy who was diagnosed with NPC. The full clinical effect in the form of reduction of the primary tumor and metastases in the lymph nodes of the neck was noted after chemo- and radiotherapy. 18 months after the cure according to the positron emission tomography, combined with computed tomography, with 18F-deoxyglucose we marked the accumulation of radiopharmaceuticals in the area of the left palatine and lingual tonsils. The examination revealed clinical signs of the soft palate papillomatosis. The resection of the soft palate was carried out. The morphological study confirmed squamous cell papilloma. HPV type 16 DNA was found in the papilloma. Conclusion. The accumulation of the information concerning childhood pharynx lesions caused by HPV would help to expand understanding of the most common types of the virus in the paediatric population. It would be possible to identify the groups of risk for the development of malignant tumors on the grounds of the detection HPV types of highly carcinogenic risk.
format	article
author	Tatiana V. Gorbunova Elena Iu. Radtsig Oleg A. Merkulov Mikhail R. Bogomil’skii Vladimir G. Poliakov
author_facet	Tatiana V. Gorbunova Elena Iu. Radtsig Oleg A. Merkulov Mikhail R. Bogomil’skii Vladimir G. Poliakov
author_sort	Tatiana V. Gorbunova
title	Virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case
title_short	Virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case
title_full	Virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case
title_fullStr	Virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case
title_full_unstemmed	Virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case
title_sort	virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case
publisher	IP Habib O.N.
publishDate	2020
url	https://doaj.org/article/daeaf2ecfe6b4665bef4ac762c93bb6b
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Virus-associated pharynx tumors in a 16-year-old boy: the description of the clinical case

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