Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis

Immunopathogenesis of rheumatoid arthritis (RA) is characterized by polyclonal activation of B lymphocytes, changes in their subpopulation composition, impaired peripheral tolerance, increased activation and differentiation of B cells, as well as deficient negative selection. Peripheral blood phenot...

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Autores principales:	L. P. Sizyakina, M. V. Kharitonova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	seronegative rheumatoid arthritis b1 cells b2 cells co-stimulating molecules flow cytometry Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/daeb15ec4a6f4bc1a2b9c0dd03260342
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spelling	oai:doaj.org-article:daeb15ec4a6f4bc1a2b9c0dd032603422021-11-18T08:03:49ZDynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis1563-06252313-741X10.15789/1563-0625-2019-6-1073-1080https://doaj.org/article/daeb15ec4a6f4bc1a2b9c0dd032603422020-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1808https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XImmunopathogenesis of rheumatoid arthritis (RA) is characterized by polyclonal activation of B lymphocytes, changes in their subpopulation composition, impaired peripheral tolerance, increased activation and differentiation of B cells, as well as deficient negative selection. Peripheral blood phenotypes of B1 and B2 lymphocytes, their correlation and response patterns in seronegative variant of articular RA type A decrease in B1 lymphocytes along with increased degree of clinical activity and duration of RA has been revealed. B2 lymphocytes remained the predominant subpopulation in peripheral blood. The studied parameters of B2 lymphocytes in the patients with disease duration of up to 5 years and more were higher than the data obtained in a control group. However, no significant changes in their dynamics were revealed upon comparative analysis. With increasing degree of clinical activity, the decreased activation potential of B2 lymphocytes was revealed, along with reduction of costimulatory signal transmission via the CD40/CD40L complex. Hence, detection of B1 and B2 lymphocytes in various types of RA may be used as diagnostic and prognostic markers.L. P. SizyakinaM. V. KharitonovaSPb RAACIarticleseronegative rheumatoid arthritisb1 cellsb2 cellsco-stimulating moleculesflow cytometryImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 6, Pp 1073-1080 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	seronegative rheumatoid arthritis b1 cells b2 cells co-stimulating molecules flow cytometry Immunologic diseases. Allergy RC581-607
spellingShingle	seronegative rheumatoid arthritis b1 cells b2 cells co-stimulating molecules flow cytometry Immunologic diseases. Allergy RC581-607 L. P. Sizyakina M. V. Kharitonova Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis
description	Immunopathogenesis of rheumatoid arthritis (RA) is characterized by polyclonal activation of B lymphocytes, changes in their subpopulation composition, impaired peripheral tolerance, increased activation and differentiation of B cells, as well as deficient negative selection. Peripheral blood phenotypes of B1 and B2 lymphocytes, their correlation and response patterns in seronegative variant of articular RA type A decrease in B1 lymphocytes along with increased degree of clinical activity and duration of RA has been revealed. B2 lymphocytes remained the predominant subpopulation in peripheral blood. The studied parameters of B2 lymphocytes in the patients with disease duration of up to 5 years and more were higher than the data obtained in a control group. However, no significant changes in their dynamics were revealed upon comparative analysis. With increasing degree of clinical activity, the decreased activation potential of B2 lymphocytes was revealed, along with reduction of costimulatory signal transmission via the CD40/CD40L complex. Hence, detection of B1 and B2 lymphocytes in various types of RA may be used as diagnostic and prognostic markers.
format	article
author	L. P. Sizyakina M. V. Kharitonova
author_facet	L. P. Sizyakina M. V. Kharitonova
author_sort	L. P. Sizyakina
title	Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis
title_short	Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis
title_full	Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis
title_fullStr	Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis
title_full_unstemmed	Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis
title_sort	dynamics of changes in b1 and b2 lymphocyte populations in articular form of seronegative rheumatoid arthritis
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/daeb15ec4a6f4bc1a2b9c0dd03260342
work_keys_str_mv	AT lpsizyakina dynamicsofchangesinb1andb2lymphocytepopulationsinarticularformofseronegativerheumatoidarthritis AT mvkharitonova dynamicsofchangesinb1andb2lymphocytepopulationsinarticularformofseronegativerheumatoidarthritis
_version_	1718422320348921856

Dynamics of changes in B1 and B2 lymphocyte populations in articular form of seronegative rheumatoid arthritis

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