Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges

Abstract Significant progress has been made during the past decade towards the clinical adoption of cell-based therapeutics. However, existing cell-delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within...

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Autores principales:	Mahetab H. Amer, Felicity R. A. J. Rose, Kevin M. Shakesheff, Michel Modo, Lisa J. White
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/daeb4140999f40de9cba00b20081aee7
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spelling	oai:doaj.org-article:daeb4140999f40de9cba00b20081aee72021-12-02T13:41:45ZTranslational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges10.1038/s41536-017-0028-x2057-3995https://doaj.org/article/daeb4140999f40de9cba00b20081aee72017-08-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0028-xhttps://doaj.org/toc/2057-3995Abstract Significant progress has been made during the past decade towards the clinical adoption of cell-based therapeutics. However, existing cell-delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of transplantation. Although consideration is being increasingly given to clinical trial design, little emphasis has been given to tools and protocols used to administer cells. The different behaviours of various cell types, dosing accuracy, precise delivery, and cell retention and viability post-injection are some of the obstacles facing clinical translation. For efficient injectable cell transplantation, accurate characterisation of cellular health post-injection and the development of standardised administration protocols are required. This review provides an overview of the challenges facing effective delivery of cell therapies, examines key studies that have been carried out to investigate injectable cell delivery, and outlines opportunities for translating these findings into more effective cell-therapy interventions.Mahetab H. AmerFelicity R. A. J. RoseKevin M. ShakesheffMichel ModoLisa J. WhiteNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Mahetab H. Amer Felicity R. A. J. Rose Kevin M. Shakesheff Michel Modo Lisa J. White Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
description	Abstract Significant progress has been made during the past decade towards the clinical adoption of cell-based therapeutics. However, existing cell-delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of transplantation. Although consideration is being increasingly given to clinical trial design, little emphasis has been given to tools and protocols used to administer cells. The different behaviours of various cell types, dosing accuracy, precise delivery, and cell retention and viability post-injection are some of the obstacles facing clinical translation. For efficient injectable cell transplantation, accurate characterisation of cellular health post-injection and the development of standardised administration protocols are required. This review provides an overview of the challenges facing effective delivery of cell therapies, examines key studies that have been carried out to investigate injectable cell delivery, and outlines opportunities for translating these findings into more effective cell-therapy interventions.
format	article
author	Mahetab H. Amer Felicity R. A. J. Rose Kevin M. Shakesheff Michel Modo Lisa J. White
author_facet	Mahetab H. Amer Felicity R. A. J. Rose Kevin M. Shakesheff Michel Modo Lisa J. White
author_sort	Mahetab H. Amer
title	Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
title_short	Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
title_full	Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
title_fullStr	Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
title_full_unstemmed	Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
title_sort	translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/daeb4140999f40de9cba00b20081aee7
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Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges

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