IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

The pro-inflammatory cytokine IL-20 promotes tumor growth in several cancer types. Here, the authors show that high levels of IL-20 are associated with poor survival in patients with pancreatic ductal adenocarcinoma (PDAC) and that IL-20 blockade reduces tumor growth and alleviates cachexia symptoms...

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Autores principales:	Shao-Wei Lu, Hong-Chin Pan, Yu-Hsiang Hsu, Kung-Chao Chang, Li-Wha Wu, Wei-Yu Chen, Ming-Shi Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/daecbc35c3a24e828aa4c37a7583f7d1
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spelling	oai:doaj.org-article:daecbc35c3a24e828aa4c37a7583f7d12021-12-02T18:33:52ZIL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models10.1038/s41467-020-18244-82041-1723https://doaj.org/article/daecbc35c3a24e828aa4c37a7583f7d12020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18244-8https://doaj.org/toc/2041-1723The pro-inflammatory cytokine IL-20 promotes tumor growth in several cancer types. Here, the authors show that high levels of IL-20 are associated with poor survival in patients with pancreatic ductal adenocarcinoma (PDAC) and that IL-20 blockade reduces tumor growth and alleviates cachexia symptoms in mouse models of PDAC.Shao-Wei LuHong-Chin PanYu-Hsiang HsuKung-Chao ChangLi-Wha WuWei-Yu ChenMing-Shi ChangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shao-Wei Lu Hong-Chin Pan Yu-Hsiang Hsu Kung-Chao Chang Li-Wha Wu Wei-Yu Chen Ming-Shi Chang IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models
description	The pro-inflammatory cytokine IL-20 promotes tumor growth in several cancer types. Here, the authors show that high levels of IL-20 are associated with poor survival in patients with pancreatic ductal adenocarcinoma (PDAC) and that IL-20 blockade reduces tumor growth and alleviates cachexia symptoms in mouse models of PDAC.
format	article
author	Shao-Wei Lu Hong-Chin Pan Yu-Hsiang Hsu Kung-Chao Chang Li-Wha Wu Wei-Yu Chen Ming-Shi Chang
author_facet	Shao-Wei Lu Hong-Chin Pan Yu-Hsiang Hsu Kung-Chao Chang Li-Wha Wu Wei-Yu Chen Ming-Shi Chang
author_sort	Shao-Wei Lu
title	IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models
title_short	IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models
title_full	IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models
title_fullStr	IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models
title_full_unstemmed	IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models
title_sort	il-20 antagonist suppresses pd-l1 expression and prolongs survival in pancreatic cancer models
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/daecbc35c3a24e828aa4c37a7583f7d1
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IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

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