Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases

Tissue engineering is biomedical engineering that uses suitable biochemical and physicochemical factors to assemble functional constructs that restore or improve damaged tissues. Recently, cell therapies as a subset of tissue engineering have been very promising in the treatment of ocular diseases....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fatemeh Sanie-Jahromi, Ali Azizi, Sahar Shariat, Mohammadkarim Johari
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/daee3945fc404b9993d60b9f301ef56c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:daee3945fc404b9993d60b9f301ef56c
record_format	dspace
spelling	oai:doaj.org-article:daee3945fc404b9993d60b9f301ef56c2021-11-29T00:56:43ZEffect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases2314-614110.1155/2021/6548554https://doaj.org/article/daee3945fc404b9993d60b9f301ef56c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6548554https://doaj.org/toc/2314-6141Tissue engineering is biomedical engineering that uses suitable biochemical and physicochemical factors to assemble functional constructs that restore or improve damaged tissues. Recently, cell therapies as a subset of tissue engineering have been very promising in the treatment of ocular diseases. One of the most important biophysical factors to make this happen is noninvasive electrical stimulation (ES) to target ocular cells that may preserve vision in multiple retinal and optic nerve diseases. The science of cellular and biophysical interactions is very exciting in regenerative medicine now. Although the exact effect of ES on cells is unknown, multiple mechanisms are considered to underlie the effects of ES, including increased production of neurotrophic agents, improved cell migration, and inhibition of proinflammatory cytokines and cellular apoptosis. In this review, we highlighted the effects of ES on ocular cells, especially on the corneal, retinal, and optic nerve cells. Initially, we summarized the current literature on the in vitro and in vivo effects of ES on ocular cells and then we provided the clinical studies describing the effect of ES on ocular complications. For each area, we used some of the most impactful articles to show the important concepts and results that advanced the state of these interactions. We conclude with reflections on emerging new areas and perspectives for future development in this field.Fatemeh Sanie-JahromiAli AziziSahar ShariatMohammadkarim JohariHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Fatemeh Sanie-Jahromi Ali Azizi Sahar Shariat Mohammadkarim Johari Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases
description	Tissue engineering is biomedical engineering that uses suitable biochemical and physicochemical factors to assemble functional constructs that restore or improve damaged tissues. Recently, cell therapies as a subset of tissue engineering have been very promising in the treatment of ocular diseases. One of the most important biophysical factors to make this happen is noninvasive electrical stimulation (ES) to target ocular cells that may preserve vision in multiple retinal and optic nerve diseases. The science of cellular and biophysical interactions is very exciting in regenerative medicine now. Although the exact effect of ES on cells is unknown, multiple mechanisms are considered to underlie the effects of ES, including increased production of neurotrophic agents, improved cell migration, and inhibition of proinflammatory cytokines and cellular apoptosis. In this review, we highlighted the effects of ES on ocular cells, especially on the corneal, retinal, and optic nerve cells. Initially, we summarized the current literature on the in vitro and in vivo effects of ES on ocular cells and then we provided the clinical studies describing the effect of ES on ocular complications. For each area, we used some of the most impactful articles to show the important concepts and results that advanced the state of these interactions. We conclude with reflections on emerging new areas and perspectives for future development in this field.
format	article
author	Fatemeh Sanie-Jahromi Ali Azizi Sahar Shariat Mohammadkarim Johari
author_facet	Fatemeh Sanie-Jahromi Ali Azizi Sahar Shariat Mohammadkarim Johari
author_sort	Fatemeh Sanie-Jahromi
title	Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases
title_short	Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases
title_full	Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases
title_fullStr	Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases
title_full_unstemmed	Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases
title_sort	effect of electrical stimulation on ocular cells: a means for improving ocular tissue engineering and treatments of eye diseases
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/daee3945fc404b9993d60b9f301ef56c
work_keys_str_mv	AT fatemehsaniejahromi effectofelectricalstimulationonocularcellsameansforimprovingoculartissueengineeringandtreatmentsofeyediseases AT aliazizi effectofelectricalstimulationonocularcellsameansforimprovingoculartissueengineeringandtreatmentsofeyediseases AT saharshariat effectofelectricalstimulationonocularcellsameansforimprovingoculartissueengineeringandtreatmentsofeyediseases AT mohammadkarimjohari effectofelectricalstimulationonocularcellsameansforimprovingoculartissueengineeringandtreatmentsofeyediseases
_version_	1718407738983186432

Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases

Ejemplares similares