Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo virus and identify a conserved epitope in the...

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Autores principales:	Lars E. Clark, Selma Mahmutovic, Donald D. Raymond, Taleen Dilanyan, Takaaki Koma, John T. Manning, Sundaresh Shankar, Silvana C. Levis, Ana M. Briggiler, Delia A. Enria, Kai W. Wucherpfennig, Slobodan Paessler, Jonathan Abraham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/daef1e9d51b8461ba2ffa8c665295132
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spelling	oai:doaj.org-article:daef1e9d51b8461ba2ffa8c6652951322021-12-02T15:33:46ZVaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses10.1038/s41467-018-04271-z2041-1723https://doaj.org/article/daef1e9d51b8461ba2ffa8c6652951322018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04271-zhttps://doaj.org/toc/2041-1723The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo virus and identify a conserved epitope in the receptor-binding domain.Lars E. ClarkSelma MahmutovicDonald D. RaymondTaleen DilanyanTakaaki KomaJohn T. ManningSundaresh ShankarSilvana C. LevisAna M. BriggilerDelia A. EnriaKai W. WucherpfennigSlobodan PaesslerJonathan AbrahamNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lars E. Clark Selma Mahmutovic Donald D. Raymond Taleen Dilanyan Takaaki Koma John T. Manning Sundaresh Shankar Silvana C. Levis Ana M. Briggiler Delia A. Enria Kai W. Wucherpfennig Slobodan Paessler Jonathan Abraham Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses
description	The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo virus and identify a conserved epitope in the receptor-binding domain.
format	article
author	Lars E. Clark Selma Mahmutovic Donald D. Raymond Taleen Dilanyan Takaaki Koma John T. Manning Sundaresh Shankar Silvana C. Levis Ana M. Briggiler Delia A. Enria Kai W. Wucherpfennig Slobodan Paessler Jonathan Abraham
author_facet	Lars E. Clark Selma Mahmutovic Donald D. Raymond Taleen Dilanyan Takaaki Koma John T. Manning Sundaresh Shankar Silvana C. Levis Ana M. Briggiler Delia A. Enria Kai W. Wucherpfennig Slobodan Paessler Jonathan Abraham
author_sort	Lars E. Clark
title	Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses
title_short	Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses
title_full	Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses
title_fullStr	Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses
title_full_unstemmed	Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses
title_sort	vaccine-elicited receptor-binding site antibodies neutralize two new world hemorrhagic fever arenaviruses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/daef1e9d51b8461ba2ffa8c665295132
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Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

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