Common host variation drives malaria parasite fitness in healthy human red cells

The replication of Plasmodium falciparum parasites within red blood cells (RBCs) causes severe disease in humans, especially in Africa. Deleterious alleles like hemoglobin S are well-known to confer strong resistance to malaria, but the effects of common RBC variation are largely undetermined. Here,...

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Auteurs principaux: Emily R Ebel, Frans A Kuypers, Carrie Lin, Dmitri A Petrov, Elizabeth S Egan
Format: article
Langue:EN
Publié: eLife Sciences Publications Ltd 2021
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/daf0b7ff78b548fd944efedacc14f915
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