Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature

Giacomo Zaccherini, Manuel Tufoni, Mauro Bernardi Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna 40138, ItalyCorrespondence: Mauro Bernardi Email mauro.bernardi@unibo.itAbstract: The use of albumin in patients with cirrhosis has been extensively di...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zaccherini G, Tufoni M, Bernardi M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	albumin ascites hepatorenal syndrome liver cirrhosis paracentesis peritonitis. Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/daf1c892805049e998608a25d61c96a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:daf1c892805049e998608a25d61c96a4
record_format	dspace
spelling	oai:doaj.org-article:daf1c892805049e998608a25d61c96a42021-12-02T12:54:43ZAlbumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature1179-1535https://doaj.org/article/daf1c892805049e998608a25d61c96a42020-10-01T00:00:00Zhttps://www.dovepress.com/albumin-administration-is-efficacious-in-the-management-of-patients-wi-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Giacomo Zaccherini, Manuel Tufoni, Mauro Bernardi Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna 40138, ItalyCorrespondence: Mauro Bernardi Email mauro.bernardi@unibo.itAbstract: The use of albumin in patients with cirrhosis has been extensively discussed over recent years. Current treatment approaches depend on targeting related complications, aiming to treat and/or prevent circulatory dysfunction, bacterial infections and multi-organ failure. Albumin has been shown to prolong survival and reduce complications in patients with cirrhosis. This review aims to ascertain whether the use of albumin is justified in patients with cirrhosis. A systematic review of randomized controlled trials (RCTs) and meta-analyses evaluating albumin use in patients with cirrhosis published between 1985 and February 2020 was conducted; the quality and risk of bias of the included studies were assessed. In total, 45 RCTs and 10 meta-analyses were included. Based on the included evidence, albumin is superior at preventing and controlling the incidence of cirrhosis complications vs other plasma expanders. Recent studies reported that long-term albumin administration to patients with decompensated cirrhosis improves survival with a 38% reduction in the mortality hazard ratio compared with standard medical treatment alone. Albumin infusions are justified for routine use in patients with cirrhosis, and the use of albumin either alone or in combination with other treatments leads to clinical benefits. Long-term administration of albumin should be considered in some patients.Keywords: albumin, ascites, hepatorenal syndrome, liver cirrhosis, paracentesis, peritonitisZaccherini GTufoni MBernardi MDove Medical Pressarticlealbuminasciteshepatorenal syndromeliver cirrhosisparacentesisperitonitis.Diseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 12, Pp 153-172 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	albumin ascites hepatorenal syndrome liver cirrhosis paracentesis peritonitis. Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	albumin ascites hepatorenal syndrome liver cirrhosis paracentesis peritonitis. Diseases of the digestive system. Gastroenterology RC799-869 Zaccherini G Tufoni M Bernardi M Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature
description	Giacomo Zaccherini, Manuel Tufoni, Mauro Bernardi Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna 40138, ItalyCorrespondence: Mauro Bernardi Email mauro.bernardi@unibo.itAbstract: The use of albumin in patients with cirrhosis has been extensively discussed over recent years. Current treatment approaches depend on targeting related complications, aiming to treat and/or prevent circulatory dysfunction, bacterial infections and multi-organ failure. Albumin has been shown to prolong survival and reduce complications in patients with cirrhosis. This review aims to ascertain whether the use of albumin is justified in patients with cirrhosis. A systematic review of randomized controlled trials (RCTs) and meta-analyses evaluating albumin use in patients with cirrhosis published between 1985 and February 2020 was conducted; the quality and risk of bias of the included studies were assessed. In total, 45 RCTs and 10 meta-analyses were included. Based on the included evidence, albumin is superior at preventing and controlling the incidence of cirrhosis complications vs other plasma expanders. Recent studies reported that long-term albumin administration to patients with decompensated cirrhosis improves survival with a 38% reduction in the mortality hazard ratio compared with standard medical treatment alone. Albumin infusions are justified for routine use in patients with cirrhosis, and the use of albumin either alone or in combination with other treatments leads to clinical benefits. Long-term administration of albumin should be considered in some patients.Keywords: albumin, ascites, hepatorenal syndrome, liver cirrhosis, paracentesis, peritonitis
format	article
author	Zaccherini G Tufoni M Bernardi M
author_facet	Zaccherini G Tufoni M Bernardi M
author_sort	Zaccherini G
title	Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature
title_short	Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature
title_full	Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature
title_fullStr	Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature
title_full_unstemmed	Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature
title_sort	albumin administration is efficacious in the management of patients with cirrhosis: a systematic review of the literature
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/daf1c892805049e998608a25d61c96a4
work_keys_str_mv	AT zaccherinig albuminadministrationisefficaciousinthemanagementofpatientswithcirrhosisasystematicreviewoftheliterature AT tufonim albuminadministrationisefficaciousinthemanagementofpatientswithcirrhosisasystematicreviewoftheliterature AT bernardim albuminadministrationisefficaciousinthemanagementofpatientswithcirrhosisasystematicreviewoftheliterature
_version_	1718393595904393216

Albumin Administration is Efficacious in the Management of Patients with Cirrhosis: A Systematic Review of the Literature

Ejemplares similares