An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer

Nanoparticles have gained increased attention due to the prospection of drug delivery at target sites, thus limiting the systemic effects of the drugs. Their efficiency was further improved by adding special carriers such as magnetite (Fe<sub>3</sub>O<sub>4</sub>). It is one...

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Autores principales:	Anroop B. Nair, Mallikarjun Telsang, Riyaz Ali Osmani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	magnetic nanoparticles gemcitabine Box–Behnken design cancer cell lines Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/daf900f38da34684a73c90483d9bd840
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spelling	oai:doaj.org-article:daf900f38da34684a73c90483d9bd8402021-11-11T18:41:44ZAn Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer10.3390/polym132136232073-4360https://doaj.org/article/daf900f38da34684a73c90483d9bd8402021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3623https://doaj.org/toc/2073-4360Nanoparticles have gained increased attention due to the prospection of drug delivery at target sites, thus limiting the systemic effects of the drugs. Their efficiency was further improved by adding special carriers such as magnetite (Fe<sub>3</sub>O<sub>4</sub>). It is one of the extensively used oxides of iron for both pharmaceutical and biomedical applications owing to its ease of preparation and biocompatibility. In this work, Gemcitabine magnetic nanoparticles were prepared using Fe<sub>3</sub>O<sub>4</sub> and chitosan as the primary ingredients. Optimization was accomplished by Box–Behnken Design and factor interactions were evaluated. The desirability function approach was made to enhance the formulation concerning particle size, polydispersity index, and zeta potential. Based on this, optimized magnetic nanoparticles (O-MNP) were formulated with 300 mg of Fe<sub>3</sub>O<sub>4</sub>, 297.7 mg of chitosan, and a sonication time of 2.4 h, which can achieve the prerequisites of the target formulation. All other in vitro parameters were found to be following the requirement. In vitro cytotoxic studies for O-MNP were performed using cell cultures of breast cancer (MCF-7), leukemia (THP-1), prostate cancer (PC-3), and lung cancer (A549). O-MNP showed maximum inhibition growth with MCF-7 cell lines rather than other cell lines. The data observed here demonstrates the potential of magnetic nanoparticles of gemcitabine in treating breast cancers.Anroop B. NairMallikarjun TelsangRiyaz Ali OsmaniMDPI AGarticlemagnetic nanoparticlesgemcitabineBox–Behnken designcancer cell linesOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3623, p 3623 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic nanoparticles gemcitabine Box–Behnken design cancer cell lines Organic chemistry QD241-441
spellingShingle	magnetic nanoparticles gemcitabine Box–Behnken design cancer cell lines Organic chemistry QD241-441 Anroop B. Nair Mallikarjun Telsang Riyaz Ali Osmani An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer
description	Nanoparticles have gained increased attention due to the prospection of drug delivery at target sites, thus limiting the systemic effects of the drugs. Their efficiency was further improved by adding special carriers such as magnetite (Fe<sub>3</sub>O<sub>4</sub>). It is one of the extensively used oxides of iron for both pharmaceutical and biomedical applications owing to its ease of preparation and biocompatibility. In this work, Gemcitabine magnetic nanoparticles were prepared using Fe<sub>3</sub>O<sub>4</sub> and chitosan as the primary ingredients. Optimization was accomplished by Box–Behnken Design and factor interactions were evaluated. The desirability function approach was made to enhance the formulation concerning particle size, polydispersity index, and zeta potential. Based on this, optimized magnetic nanoparticles (O-MNP) were formulated with 300 mg of Fe<sub>3</sub>O<sub>4</sub>, 297.7 mg of chitosan, and a sonication time of 2.4 h, which can achieve the prerequisites of the target formulation. All other in vitro parameters were found to be following the requirement. In vitro cytotoxic studies for O-MNP were performed using cell cultures of breast cancer (MCF-7), leukemia (THP-1), prostate cancer (PC-3), and lung cancer (A549). O-MNP showed maximum inhibition growth with MCF-7 cell lines rather than other cell lines. The data observed here demonstrates the potential of magnetic nanoparticles of gemcitabine in treating breast cancers.
format	article
author	Anroop B. Nair Mallikarjun Telsang Riyaz Ali Osmani
author_facet	Anroop B. Nair Mallikarjun Telsang Riyaz Ali Osmani
author_sort	Anroop B. Nair
title	An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer
title_short	An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer
title_full	An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer
title_fullStr	An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer
title_full_unstemmed	An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer
title_sort	engineered specificity of anti-neoplastic agent loaded magnetic nanoparticles for the treatment of breast cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/daf900f38da34684a73c90483d9bd840
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An Engineered Specificity of Anti-Neoplastic Agent Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer

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