A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics

Abstract Background This study aimed to classify the distinct group of patients with axial spondyloarthritis (SpA) on tumour necrosis factor alpha inhibitors (TNFi) according to the baseline characteristics using a clustering algorithm. Methods The clinical characteristics and demographic data of pa...

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Autores principales:	Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hong-Hee Won, Hyungjin Kim, Hoon-Suk Cha, Eun-Mi Koh, Jaejoon Lee
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Spondyloarthritis TNF Cluster analysis Drug survival Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/dafb7014795240c296d53e36484abd95
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spelling	oai:doaj.org-article:dafb7014795240c296d53e36484abd952021-11-21T12:03:45ZA cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics10.1186/s13075-021-02647-z1478-6362https://doaj.org/article/dafb7014795240c296d53e36484abd952021-11-01T00:00:00Zhttps://doi.org/10.1186/s13075-021-02647-zhttps://doaj.org/toc/1478-6362Abstract Background This study aimed to classify the distinct group of patients with axial spondyloarthritis (SpA) on tumour necrosis factor alpha inhibitors (TNFi) according to the baseline characteristics using a clustering algorithm. Methods The clinical characteristics and demographic data of patients with axial SpA included in the Korean College of Rheumatology Biologics and Targeted Therapy registry were investigated. The patterns of disease manifestations were examined using divisive hierarchical cluster analysis. After clustering, we compared the clinical characteristics of patients and the drug survival of TNFi between the classified groups. Results A total of 1042 patients were analysed. The cluster analysis classified patients into two groups: axial group predominantly showing isolated axial manifestations (n = 828) and extra-axial group more frequently showing extra-axial symptoms (n = 214). Almost all extra-axial symptoms (peripheral arthritis, enthesitis, uveitis, and psoriasis) were more frequently observed in the extra-axial group than in the axial group. Moreover, patients in the extra-axial group had shorter disease duration, later disease onset, and higher disease activity than those in the axial group. The disease activity was comparable between the two groups after 1 year of treatment with TNFi. Interestingly, the extra-axial group had a lower drug survival with TNFi than the axial group (p = 0.001). Conclusions Cluster analysis of patients with axial SpA using TNFi classified two distinct clinical phenotypes. These clusters had different TNFi drug survival, clinical characteristics, and disease activity.Seulkee LeeSeonyoung KangYeonghee EunHong-Hee WonHyungjin KimHoon-Suk ChaEun-Mi KohJaejoon LeeBMCarticleSpondyloarthritisTNFCluster analysisDrug survivalDiseases of the musculoskeletal systemRC925-935ENArthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spondyloarthritis TNF Cluster analysis Drug survival Diseases of the musculoskeletal system RC925-935
spellingShingle	Spondyloarthritis TNF Cluster analysis Drug survival Diseases of the musculoskeletal system RC925-935 Seulkee Lee Seonyoung Kang Yeonghee Eun Hong-Hee Won Hyungjin Kim Hoon-Suk Cha Eun-Mi Koh Jaejoon Lee A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics
description	Abstract Background This study aimed to classify the distinct group of patients with axial spondyloarthritis (SpA) on tumour necrosis factor alpha inhibitors (TNFi) according to the baseline characteristics using a clustering algorithm. Methods The clinical characteristics and demographic data of patients with axial SpA included in the Korean College of Rheumatology Biologics and Targeted Therapy registry were investigated. The patterns of disease manifestations were examined using divisive hierarchical cluster analysis. After clustering, we compared the clinical characteristics of patients and the drug survival of TNFi between the classified groups. Results A total of 1042 patients were analysed. The cluster analysis classified patients into two groups: axial group predominantly showing isolated axial manifestations (n = 828) and extra-axial group more frequently showing extra-axial symptoms (n = 214). Almost all extra-axial symptoms (peripheral arthritis, enthesitis, uveitis, and psoriasis) were more frequently observed in the extra-axial group than in the axial group. Moreover, patients in the extra-axial group had shorter disease duration, later disease onset, and higher disease activity than those in the axial group. The disease activity was comparable between the two groups after 1 year of treatment with TNFi. Interestingly, the extra-axial group had a lower drug survival with TNFi than the axial group (p = 0.001). Conclusions Cluster analysis of patients with axial SpA using TNFi classified two distinct clinical phenotypes. These clusters had different TNFi drug survival, clinical characteristics, and disease activity.
format	article
author	Seulkee Lee Seonyoung Kang Yeonghee Eun Hong-Hee Won Hyungjin Kim Hoon-Suk Cha Eun-Mi Koh Jaejoon Lee
author_facet	Seulkee Lee Seonyoung Kang Yeonghee Eun Hong-Hee Won Hyungjin Kim Hoon-Suk Cha Eun-Mi Koh Jaejoon Lee
author_sort	Seulkee Lee
title	A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics
title_short	A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics
title_full	A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics
title_fullStr	A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics
title_full_unstemmed	A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics
title_sort	cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics
publisher	BMC
publishDate	2021
url	https://doaj.org/article/dafb7014795240c296d53e36484abd95
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A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics

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