In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives

Essential oil of Elettaria cardamomum (Green cardamom) is effective in the treatment of various disease conditions. Globally, Guatemala is the leading producer of green cardamom fruits. Green-cardamom fruits from Guatemala were purchased from a Saudi Arabian market. The Guatemala cardamom essential...

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Autores principales:	Aftab Alam, Talha jawaid, Pravej Alam
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	guatemala cardamom essential oil chemical composition antioxidant anti-inflammatory in silico study Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/dafcc86791134851a6bf56e8a55a29ba
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spelling	oai:doaj.org-article:dafcc86791134851a6bf56e8a55a29ba2021-11-26T11:19:47ZIn vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives1658-365510.1080/16583655.2021.2002550https://doaj.org/article/dafcc86791134851a6bf56e8a55a29ba2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/16583655.2021.2002550https://doaj.org/toc/1658-3655Essential oil of Elettaria cardamomum (Green cardamom) is effective in the treatment of various disease conditions. Globally, Guatemala is the leading producer of green cardamom fruits. Green-cardamom fruits from Guatemala were purchased from a Saudi Arabian market. The Guatemala cardamom essential oil (GCEO) was extracted using hydro-distillation method, and analyzed using gaschromatography/ mass-spectrometry (GC-MS). The antioxidant and anti-inflammatory activities were studied using 2,2-diphenyl-1-picrylhydrazyl-hydrate, ferric-chloride, bovine serum-albumin and proteinase inhibitory assays. GC-MS results confirmed the presence of α- terpinyl acetate and 1,8-cineole as major components. The antioxidant and anti-inflammatory activities of GCEO were found to be significant compared with those of standard ascorbic acid and ibuprofen, respectively. The molecular-docking study revealed the considerable binding potential of α-terpinyl acetate and 1,8-cineole with human-peroxiredoxin-5, tyrosine-kinases and Human-5-LOX receptors. The in-silico activity prediction analysis confirmed the antioxidant and anti-inflammatory potential, whereas the pharmacokinetics confirmed the safety of most of the GCEO compounds.Aftab AlamTalha jawaidPravej AlamTaylor & Francis Grouparticleguatemala cardamomessential oilchemical compositionantioxidantanti-inflammatoryin silico studyScience (General)Q1-390ENJournal of Taibah University for Science, Vol 15, Iss 1, Pp 757-768 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	guatemala cardamom essential oil chemical composition antioxidant anti-inflammatory in silico study Science (General) Q1-390
spellingShingle	guatemala cardamom essential oil chemical composition antioxidant anti-inflammatory in silico study Science (General) Q1-390 Aftab Alam Talha jawaid Pravej Alam In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives
description	Essential oil of Elettaria cardamomum (Green cardamom) is effective in the treatment of various disease conditions. Globally, Guatemala is the leading producer of green cardamom fruits. Green-cardamom fruits from Guatemala were purchased from a Saudi Arabian market. The Guatemala cardamom essential oil (GCEO) was extracted using hydro-distillation method, and analyzed using gaschromatography/ mass-spectrometry (GC-MS). The antioxidant and anti-inflammatory activities were studied using 2,2-diphenyl-1-picrylhydrazyl-hydrate, ferric-chloride, bovine serum-albumin and proteinase inhibitory assays. GC-MS results confirmed the presence of α- terpinyl acetate and 1,8-cineole as major components. The antioxidant and anti-inflammatory activities of GCEO were found to be significant compared with those of standard ascorbic acid and ibuprofen, respectively. The molecular-docking study revealed the considerable binding potential of α-terpinyl acetate and 1,8-cineole with human-peroxiredoxin-5, tyrosine-kinases and Human-5-LOX receptors. The in-silico activity prediction analysis confirmed the antioxidant and anti-inflammatory potential, whereas the pharmacokinetics confirmed the safety of most of the GCEO compounds.
format	article
author	Aftab Alam Talha jawaid Pravej Alam
author_facet	Aftab Alam Talha jawaid Pravej Alam
author_sort	Aftab Alam
title	In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives
title_short	In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives
title_full	In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives
title_fullStr	In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives
title_full_unstemmed	In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives
title_sort	in vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/dafcc86791134851a6bf56e8a55a29ba
work_keys_str_mv	AT aftabalam invitroantioxidantandantiinflammatoryactivitiesofgreencardamomessentialoilandinsilicomoleculardockingofitsmajorbioactives AT talhajawaid invitroantioxidantandantiinflammatoryactivitiesofgreencardamomessentialoilandinsilicomoleculardockingofitsmajorbioactives AT pravejalam invitroantioxidantandantiinflammatoryactivitiesofgreencardamomessentialoilandinsilicomoleculardockingofitsmajorbioactives
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In vitro antioxidant and anti-inflammatory activities of green cardamom essential oil and in silico molecular docking of its major bioactives

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