The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways

Abstract The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has revealed canonical and noncanonical functions of long and small ncRNAs, including microRNAs, long ncRNAs (lncRNAs), circular RNAs, PIWI-interacting R...

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Autores principales:	Ming-Che Kuo, Sam Chi-Hao Liu, Ya-Fang Hsu, Ruey-Meei Wu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Noncoding RNA Parkinson’s disease MicroRNA/miRNA PIWI-interacting RNA/piRNA Circular RNA/circRNA Long noncoding RNA/lncRNA Medicine R
Acceso en línea:	https://doaj.org/article/daff1174a53c42fbb9017851eede234f
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spelling	oai:doaj.org-article:daff1174a53c42fbb9017851eede234f2021-11-21T12:14:48ZThe role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways10.1186/s12929-021-00775-x1423-0127https://doaj.org/article/daff1174a53c42fbb9017851eede234f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12929-021-00775-xhttps://doaj.org/toc/1423-0127Abstract The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has revealed canonical and noncanonical functions of long and small ncRNAs, including microRNAs, long ncRNAs (lncRNAs), circular RNAs, PIWI-interacting RNAs, and tRNA-derived fragments. These ncRNAs have the ability to regulate gene expression and modify metabolic pathways. Thus, they may have important roles as diagnostic biomarkers or therapeutic targets in various diseases, including neurodegenerative disorders, especially Parkinson’s disease. Recently, through diverse sequencing technologies and a wide variety of bioinformatic analytical tools, such as reverse transcriptase quantitative PCR, microarrays, next-generation sequencing and long-read sequencing, numerous ncRNAs have been shown to be associated with neurodegenerative disorders, including Parkinson’s disease. In this review article, we will first introduce the biogenesis of different ncRNAs, including microRNAs, PIWI-interacting RNAs, circular RNAs, long noncoding RNAs, and tRNA-derived fragments. The pros and cons of the detection platforms of ncRNAs and the reproducibility of bioinformatic analytical tools will be discussed in the second part. Finally, the recent discovery of numerous PD-associated ncRNAs and their association with the diagnosis and pathophysiology of PD are reviewed, and microRNAs and long ncRNAs that are transported by exosomes in biofluids are particularly emphasized.Ming-Che KuoSam Chi-Hao LiuYa-Fang HsuRuey-Meei WuBMCarticleNoncoding RNAParkinson’s diseaseMicroRNA/miRNAPIWI-interacting RNA/piRNACircular RNA/circRNALong noncoding RNA/lncRNAMedicineRENJournal of Biomedical Science, Vol 28, Iss 1, Pp 1-28 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Noncoding RNA Parkinson’s disease MicroRNA/miRNA PIWI-interacting RNA/piRNA Circular RNA/circRNA Long noncoding RNA/lncRNA Medicine R
spellingShingle	Noncoding RNA Parkinson’s disease MicroRNA/miRNA PIWI-interacting RNA/piRNA Circular RNA/circRNA Long noncoding RNA/lncRNA Medicine R Ming-Che Kuo Sam Chi-Hao Liu Ya-Fang Hsu Ruey-Meei Wu The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways
description	Abstract The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has revealed canonical and noncanonical functions of long and small ncRNAs, including microRNAs, long ncRNAs (lncRNAs), circular RNAs, PIWI-interacting RNAs, and tRNA-derived fragments. These ncRNAs have the ability to regulate gene expression and modify metabolic pathways. Thus, they may have important roles as diagnostic biomarkers or therapeutic targets in various diseases, including neurodegenerative disorders, especially Parkinson’s disease. Recently, through diverse sequencing technologies and a wide variety of bioinformatic analytical tools, such as reverse transcriptase quantitative PCR, microarrays, next-generation sequencing and long-read sequencing, numerous ncRNAs have been shown to be associated with neurodegenerative disorders, including Parkinson’s disease. In this review article, we will first introduce the biogenesis of different ncRNAs, including microRNAs, PIWI-interacting RNAs, circular RNAs, long noncoding RNAs, and tRNA-derived fragments. The pros and cons of the detection platforms of ncRNAs and the reproducibility of bioinformatic analytical tools will be discussed in the second part. Finally, the recent discovery of numerous PD-associated ncRNAs and their association with the diagnosis and pathophysiology of PD are reviewed, and microRNAs and long ncRNAs that are transported by exosomes in biofluids are particularly emphasized.
format	article
author	Ming-Che Kuo Sam Chi-Hao Liu Ya-Fang Hsu Ruey-Meei Wu
author_facet	Ming-Che Kuo Sam Chi-Hao Liu Ya-Fang Hsu Ruey-Meei Wu
author_sort	Ming-Che Kuo
title	The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways
title_short	The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways
title_full	The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways
title_fullStr	The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways
title_full_unstemmed	The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways
title_sort	role of noncoding rnas in parkinson’s disease: biomarkers and associations with pathogenic pathways
publisher	BMC
publishDate	2021
url	https://doaj.org/article/daff1174a53c42fbb9017851eede234f
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The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways

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