CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

EZH2 phosphorylation by CDK2 promotes progression of triple-negative breast cancer (TNBC). Here, the authors show that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.

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Autores principales:	Lei Nie, Yongkun Wei, Fei Zhang, Yi-Hsin Hsu, Li-Chuan Chan, Weiya Xia, Baozhen Ke, Cihui Zhu, Rong Deng, Jun Tang, Jun Yao, Yu-Yi Chu, Xixi Zhao, Ye Han, Junwei Hou, Longfei Huo, How-Wen Ko, Wan-Chi Lin, Hirohito Yamaguchi, Jung-Mao Hsu, Yi Yang, Dean N. Pan, Jennifer L. Hsu, Celina G. Kleer, Nancy E. Davidson, Gabriel N. Hortobagyi, Mien-Chie Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db070b7abc844972aa2cc8c48facb949
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spelling	oai:doaj.org-article:db070b7abc844972aa2cc8c48facb9492021-12-02T14:38:46ZCDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer10.1038/s41467-019-13105-52041-1723https://doaj.org/article/db070b7abc844972aa2cc8c48facb9492019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13105-5https://doaj.org/toc/2041-1723EZH2 phosphorylation by CDK2 promotes progression of triple-negative breast cancer (TNBC). Here, the authors show that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.Lei NieYongkun WeiFei ZhangYi-Hsin HsuLi-Chuan ChanWeiya XiaBaozhen KeCihui ZhuRong DengJun TangJun YaoYu-Yi ChuXixi ZhaoYe HanJunwei HouLongfei HuoHow-Wen KoWan-Chi LinHirohito YamaguchiJung-Mao HsuYi YangDean N. PanJennifer L. HsuCelina G. KleerNancy E. DavidsonGabriel N. HortobagyiMien-Chie HungNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Nie Yongkun Wei Fei Zhang Yi-Hsin Hsu Li-Chuan Chan Weiya Xia Baozhen Ke Cihui Zhu Rong Deng Jun Tang Jun Yao Yu-Yi Chu Xixi Zhao Ye Han Junwei Hou Longfei Huo How-Wen Ko Wan-Chi Lin Hirohito Yamaguchi Jung-Mao Hsu Yi Yang Dean N. Pan Jennifer L. Hsu Celina G. Kleer Nancy E. Davidson Gabriel N. Hortobagyi Mien-Chie Hung CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
description	EZH2 phosphorylation by CDK2 promotes progression of triple-negative breast cancer (TNBC). Here, the authors show that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.
format	article
author	Lei Nie Yongkun Wei Fei Zhang Yi-Hsin Hsu Li-Chuan Chan Weiya Xia Baozhen Ke Cihui Zhu Rong Deng Jun Tang Jun Yao Yu-Yi Chu Xixi Zhao Ye Han Junwei Hou Longfei Huo How-Wen Ko Wan-Chi Lin Hirohito Yamaguchi Jung-Mao Hsu Yi Yang Dean N. Pan Jennifer L. Hsu Celina G. Kleer Nancy E. Davidson Gabriel N. Hortobagyi Mien-Chie Hung
author_facet	Lei Nie Yongkun Wei Fei Zhang Yi-Hsin Hsu Li-Chuan Chan Weiya Xia Baozhen Ke Cihui Zhu Rong Deng Jun Tang Jun Yao Yu-Yi Chu Xixi Zhao Ye Han Junwei Hou Longfei Huo How-Wen Ko Wan-Chi Lin Hirohito Yamaguchi Jung-Mao Hsu Yi Yang Dean N. Pan Jennifer L. Hsu Celina G. Kleer Nancy E. Davidson Gabriel N. Hortobagyi Mien-Chie Hung
author_sort	Lei Nie
title	CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
title_short	CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
title_full	CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
title_fullStr	CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
title_full_unstemmed	CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
title_sort	cdk2-mediated site-specific phosphorylation of ezh2 drives and maintains triple-negative breast cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/db070b7abc844972aa2cc8c48facb949
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CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

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