Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers

The small proton-coupled transporter EmrE confers multidrug resistance in bacteria. The structure of drug-bound EmrE in phospholipid bilayers is now determined using solid-state NMR. The structure provides detailed insights into the molecular mechanism of substrate recognition by this transporter.

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Autores principales:	Alexander A. Shcherbakov, Grant Hisao, Venkata S. Mandala, Nathan E. Thomas, Mohammad Soltani, E. A. Salter, James H. Davis, Katherine A. Henzler-Wildman, Mei Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db0829dbaea348d0bf08d38e1f44870d
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spelling	oai:doaj.org-article:db0829dbaea348d0bf08d38e1f44870d2021-12-02T15:16:22ZStructure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers10.1038/s41467-020-20468-72041-1723https://doaj.org/article/db0829dbaea348d0bf08d38e1f44870d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20468-7https://doaj.org/toc/2041-1723The small proton-coupled transporter EmrE confers multidrug resistance in bacteria. The structure of drug-bound EmrE in phospholipid bilayers is now determined using solid-state NMR. The structure provides detailed insights into the molecular mechanism of substrate recognition by this transporter.Alexander A. ShcherbakovGrant HisaoVenkata S. MandalaNathan E. ThomasMohammad SoltaniE. A. SalterJames H. DavisKatherine A. Henzler-WildmanMei HongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander A. Shcherbakov Grant Hisao Venkata S. Mandala Nathan E. Thomas Mohammad Soltani E. A. Salter James H. Davis Katherine A. Henzler-Wildman Mei Hong Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers
description	The small proton-coupled transporter EmrE confers multidrug resistance in bacteria. The structure of drug-bound EmrE in phospholipid bilayers is now determined using solid-state NMR. The structure provides detailed insights into the molecular mechanism of substrate recognition by this transporter.
format	article
author	Alexander A. Shcherbakov Grant Hisao Venkata S. Mandala Nathan E. Thomas Mohammad Soltani E. A. Salter James H. Davis Katherine A. Henzler-Wildman Mei Hong
author_facet	Alexander A. Shcherbakov Grant Hisao Venkata S. Mandala Nathan E. Thomas Mohammad Soltani E. A. Salter James H. Davis Katherine A. Henzler-Wildman Mei Hong
author_sort	Alexander A. Shcherbakov
title	Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers
title_short	Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers
title_full	Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers
title_fullStr	Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers
title_full_unstemmed	Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers
title_sort	structure and dynamics of the drug-bound bacterial transporter emre in lipid bilayers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db0829dbaea348d0bf08d38e1f44870d
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Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers

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