The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages

The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages

The virulence factor MgtC is essential for intracellular macrophage survival of Salmonella enterica. Here, the authors show that MgtC targets the PhoB/PhoR regulatory system leading to phosphate uptake inside macrophages and that both phoR mutation and phoB deletion renders Salmonella hypervirulent...

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Autores principales: Soomin Choi, Eunna Choi, Yong-Joon Cho, Daesil Nam, Jangwoo Lee, Eun-Jin Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/db0a246775a94deda6c613159f9bd353
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spelling oai:doaj.org-article:db0a246775a94deda6c613159f9bd3532021-12-02T17:01:52ZThe Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages10.1038/s41467-019-11318-22041-1723https://doaj.org/article/db0a246775a94deda6c613159f9bd3532019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11318-2https://doaj.org/toc/2041-1723The virulence factor MgtC is essential for intracellular macrophage survival of Salmonella enterica. Here, the authors show that MgtC targets the PhoB/PhoR regulatory system leading to phosphate uptake inside macrophages and that both phoR mutation and phoB deletion renders Salmonella hypervirulent in mice.Soomin ChoiEunna ChoiYong-Joon ChoDaesil NamJangwoo LeeEun-Jin LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Soomin Choi
Eunna Choi
Yong-Joon Cho
Daesil Nam
Jangwoo Lee
Eun-Jin Lee
The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages
description The virulence factor MgtC is essential for intracellular macrophage survival of Salmonella enterica. Here, the authors show that MgtC targets the PhoB/PhoR regulatory system leading to phosphate uptake inside macrophages and that both phoR mutation and phoB deletion renders Salmonella hypervirulent in mice.
format article
author Soomin Choi
Eunna Choi
Yong-Joon Cho
Daesil Nam
Jangwoo Lee
Eun-Jin Lee
author_facet Soomin Choi
Eunna Choi
Yong-Joon Cho
Daesil Nam
Jangwoo Lee
Eun-Jin Lee
author_sort Soomin Choi
title The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages
title_short The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages
title_full The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages
title_fullStr The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages
title_full_unstemmed The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages
title_sort salmonella virulence protein mgtc promotes phosphate uptake inside macrophages
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/db0a246775a94deda6c613159f9bd353
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