Effect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens

Salmonellosis, caused by Salmonella Enteritidis, is a prevalent zoonosis that has serious consequences for human health and the development of the poultry sector. The Salmonella Enteritis live vaccine (Sm24/Rif12/Ssq strain) is used to prevent Salmonella Enteritidis around the world. However, in som...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiangang Hu, Chuanyan Che, Jiakun Zuo, Xiangpeng Niu, Zhihao Wang, Liyan Lian, Yuanzheng Jia, Haiyang Zhang, Tao Zhang, Fangheng Yu, Saqib Nawaz, Xiangan Han
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Salmonella Enteritidis live vaccine antibiotics colonization bacterial isolation Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/db0a9e2b93744844b2177114952a4176
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:db0a9e2b93744844b2177114952a4176
record_format	dspace
spelling	oai:doaj.org-article:db0a9e2b93744844b2177114952a41762021-12-01T22:08:03ZEffect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens2297-176910.3389/fvets.2021.784160https://doaj.org/article/db0a9e2b93744844b2177114952a41762021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.784160/fullhttps://doaj.org/toc/2297-1769Salmonellosis, caused by Salmonella Enteritidis, is a prevalent zoonosis that has serious consequences for human health and the development of the poultry sector. The Salmonella Enteritis live vaccine (Sm24/Rif12/Ssq strain) is used to prevent Salmonella Enteritidis around the world. However, in some parts of the world, poultry flocks are frequently raised under intensive conditions, with significant amounts of antimicrobials to prevent and treat disease and to promote growth. To investigate whether antibiotic use influences the colonization of orally administered Salmonella live vaccines, 240 1-day-old specific pathogen-free chicks were randomly divided into 24 groups of 10 animals for this study. The different groups were treated with different antibiotics, which included ceftiofur, amoxicillin, enrofloxacin, and lincomycin–spectinomycin. Each group was immunized 2, 3, 4, and 5 days after withdrawal, respectively. At 5 days after immunization, the blood, liver, and ceca with contents were collected for the isolation of the Salmonella live vaccine strain. The result showed that no Salmonella vaccine strain was isolated in the blood and liver of the chicks in those groups. The highest number of Salmonella vaccine strains was isolated in the cecum from chicks vaccinated 2 days after ceftiofur withdrawal, and no Salmonella vaccine strain was isolated from the cecum in chicks immunized 3 days after ceftiofur withdrawal. Among the chickens immunized 4 days after the withdrawal of amoxicillin, enrofloxacin, and lincomycin–spectinomycin, the number of Salmonella vaccine colonization in the cecum was the highest, which was higher than that of the chickens immunized at other withdrawal interval (2, 3, and 5 days) groups and was higher than that of the chickens without treatment (P < 0.05). This study provides a reference for the effective use of the Salmonella Enteritidis live vaccine and key antibiotics commonly utilized in the poultry industry.Jiangang HuChuanyan CheJiakun ZuoXiangpeng NiuZhihao WangLiyan LianYuanzheng JiaHaiyang ZhangTao ZhangFangheng YuSaqib NawazXiangan HanFrontiers Media S.A.articleSalmonella Enteritidislive vaccineantibioticscolonizationbacterial isolationVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Salmonella Enteritidis live vaccine antibiotics colonization bacterial isolation Veterinary medicine SF600-1100
spellingShingle	Salmonella Enteritidis live vaccine antibiotics colonization bacterial isolation Veterinary medicine SF600-1100 Jiangang Hu Chuanyan Che Jiakun Zuo Xiangpeng Niu Zhihao Wang Liyan Lian Yuanzheng Jia Haiyang Zhang Tao Zhang Fangheng Yu Saqib Nawaz Xiangan Han Effect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens
description	Salmonellosis, caused by Salmonella Enteritidis, is a prevalent zoonosis that has serious consequences for human health and the development of the poultry sector. The Salmonella Enteritis live vaccine (Sm24/Rif12/Ssq strain) is used to prevent Salmonella Enteritidis around the world. However, in some parts of the world, poultry flocks are frequently raised under intensive conditions, with significant amounts of antimicrobials to prevent and treat disease and to promote growth. To investigate whether antibiotic use influences the colonization of orally administered Salmonella live vaccines, 240 1-day-old specific pathogen-free chicks were randomly divided into 24 groups of 10 animals for this study. The different groups were treated with different antibiotics, which included ceftiofur, amoxicillin, enrofloxacin, and lincomycin–spectinomycin. Each group was immunized 2, 3, 4, and 5 days after withdrawal, respectively. At 5 days after immunization, the blood, liver, and ceca with contents were collected for the isolation of the Salmonella live vaccine strain. The result showed that no Salmonella vaccine strain was isolated in the blood and liver of the chicks in those groups. The highest number of Salmonella vaccine strains was isolated in the cecum from chicks vaccinated 2 days after ceftiofur withdrawal, and no Salmonella vaccine strain was isolated from the cecum in chicks immunized 3 days after ceftiofur withdrawal. Among the chickens immunized 4 days after the withdrawal of amoxicillin, enrofloxacin, and lincomycin–spectinomycin, the number of Salmonella vaccine colonization in the cecum was the highest, which was higher than that of the chickens immunized at other withdrawal interval (2, 3, and 5 days) groups and was higher than that of the chickens without treatment (P < 0.05). This study provides a reference for the effective use of the Salmonella Enteritidis live vaccine and key antibiotics commonly utilized in the poultry industry.
format	article
author	Jiangang Hu Chuanyan Che Jiakun Zuo Xiangpeng Niu Zhihao Wang Liyan Lian Yuanzheng Jia Haiyang Zhang Tao Zhang Fangheng Yu Saqib Nawaz Xiangan Han
author_facet	Jiangang Hu Chuanyan Che Jiakun Zuo Xiangpeng Niu Zhihao Wang Liyan Lian Yuanzheng Jia Haiyang Zhang Tao Zhang Fangheng Yu Saqib Nawaz Xiangan Han
author_sort	Jiangang Hu
title	Effect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens
title_short	Effect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens
title_full	Effect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens
title_fullStr	Effect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens
title_full_unstemmed	Effect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens
title_sort	effect of antibiotics on the colonization of live attenuated salmonella enteritidis vaccine in chickens
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/db0a9e2b93744844b2177114952a4176
work_keys_str_mv	AT jianganghu effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT chuanyanche effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT jiakunzuo effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT xiangpengniu effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT zhihaowang effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT liyanlian effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT yuanzhengjia effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT haiyangzhang effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT taozhang effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT fanghengyu effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT saqibnawaz effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens AT xianganhan effectofantibioticsonthecolonizationofliveattenuatedsalmonellaenteritidisvaccineinchickens
_version_	1718404191265751040

Effect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens

Ejemplares similares