Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation

D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice.

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Auteurs principaux:	Iku Tsutsui-Kimura, Hiroyuki Takiue, Keitaro Yoshida, Ming Xu, Ryutaro Yano, Hiroyuki Ohta, Hiroshi Nishida, Youcef Bouchekioua, Hideyuki Okano, Motokazu Uchigashima, Masahiko Watanabe, Norio Takata, Michael R. Drew, Hiromi Sano, Masaru Mimura, Kenji F. Tanaka
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/db122104311e48c9b21cce00826f3e10
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spelling	oai:doaj.org-article:db122104311e48c9b21cce00826f3e102021-12-02T14:41:08ZDysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation10.1038/ncomms143042041-1723https://doaj.org/article/db122104311e48c9b21cce00826f3e102017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14304https://doaj.org/toc/2041-1723D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice.Iku Tsutsui-KimuraHiroyuki TakiueKeitaro YoshidaMing XuRyutaro YanoHiroyuki OhtaHiroshi NishidaYoucef BouchekiouaHideyuki OkanoMotokazu UchigashimaMasahiko WatanabeNorio TakataMichael R. DrewHiromi SanoMasaru MimuraKenji F. TanakaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iku Tsutsui-Kimura Hiroyuki Takiue Keitaro Yoshida Ming Xu Ryutaro Yano Hiroyuki Ohta Hiroshi Nishida Youcef Bouchekioua Hideyuki Okano Motokazu Uchigashima Masahiko Watanabe Norio Takata Michael R. Drew Hiromi Sano Masaru Mimura Kenji F. Tanaka Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
description	D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice.
format	article
author	Iku Tsutsui-Kimura Hiroyuki Takiue Keitaro Yoshida Ming Xu Ryutaro Yano Hiroyuki Ohta Hiroshi Nishida Youcef Bouchekioua Hideyuki Okano Motokazu Uchigashima Masahiko Watanabe Norio Takata Michael R. Drew Hiromi Sano Masaru Mimura Kenji F. Tanaka
author_facet	Iku Tsutsui-Kimura Hiroyuki Takiue Keitaro Yoshida Ming Xu Ryutaro Yano Hiroyuki Ohta Hiroshi Nishida Youcef Bouchekioua Hideyuki Okano Motokazu Uchigashima Masahiko Watanabe Norio Takata Michael R. Drew Hiromi Sano Masaru Mimura Kenji F. Tanaka
author_sort	Iku Tsutsui-Kimura
title	Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_short	Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_full	Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_fullStr	Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_full_unstemmed	Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_sort	dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/db122104311e48c9b21cce00826f3e10
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Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation

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