Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation

D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice.

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Autores principales: Iku Tsutsui-Kimura, Hiroyuki Takiue, Keitaro Yoshida, Ming Xu, Ryutaro Yano, Hiroyuki Ohta, Hiroshi Nishida, Youcef Bouchekioua, Hideyuki Okano, Motokazu Uchigashima, Masahiko Watanabe, Norio Takata, Michael R. Drew, Hiromi Sano, Masaru Mimura, Kenji F. Tanaka
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/db122104311e48c9b21cce00826f3e10
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spelling oai:doaj.org-article:db122104311e48c9b21cce00826f3e102021-12-02T14:41:08ZDysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation10.1038/ncomms143042041-1723https://doaj.org/article/db122104311e48c9b21cce00826f3e102017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14304https://doaj.org/toc/2041-1723D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice.Iku Tsutsui-KimuraHiroyuki TakiueKeitaro YoshidaMing XuRyutaro YanoHiroyuki OhtaHiroshi NishidaYoucef BouchekiouaHideyuki OkanoMotokazu UchigashimaMasahiko WatanabeNorio TakataMichael R. DrewHiromi SanoMasaru MimuraKenji F. TanakaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Iku Tsutsui-Kimura
Hiroyuki Takiue
Keitaro Yoshida
Ming Xu
Ryutaro Yano
Hiroyuki Ohta
Hiroshi Nishida
Youcef Bouchekioua
Hideyuki Okano
Motokazu Uchigashima
Masahiko Watanabe
Norio Takata
Michael R. Drew
Hiromi Sano
Masaru Mimura
Kenji F. Tanaka
Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
description D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice.
format article
author Iku Tsutsui-Kimura
Hiroyuki Takiue
Keitaro Yoshida
Ming Xu
Ryutaro Yano
Hiroyuki Ohta
Hiroshi Nishida
Youcef Bouchekioua
Hideyuki Okano
Motokazu Uchigashima
Masahiko Watanabe
Norio Takata
Michael R. Drew
Hiromi Sano
Masaru Mimura
Kenji F. Tanaka
author_facet Iku Tsutsui-Kimura
Hiroyuki Takiue
Keitaro Yoshida
Ming Xu
Ryutaro Yano
Hiroyuki Ohta
Hiroshi Nishida
Youcef Bouchekioua
Hideyuki Okano
Motokazu Uchigashima
Masahiko Watanabe
Norio Takata
Michael R. Drew
Hiromi Sano
Masaru Mimura
Kenji F. Tanaka
author_sort Iku Tsutsui-Kimura
title Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_short Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_full Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_fullStr Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_full_unstemmed Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
title_sort dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/db122104311e48c9b21cce00826f3e10
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