Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation
D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice.
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2017
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oai:doaj.org-article:db122104311e48c9b21cce00826f3e102021-12-02T14:41:08ZDysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation10.1038/ncomms143042041-1723https://doaj.org/article/db122104311e48c9b21cce00826f3e102017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14304https://doaj.org/toc/2041-1723D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice.Iku Tsutsui-KimuraHiroyuki TakiueKeitaro YoshidaMing XuRyutaro YanoHiroyuki OhtaHiroshi NishidaYoucef BouchekiouaHideyuki OkanoMotokazu UchigashimaMasahiko WatanabeNorio TakataMichael R. DrewHiromi SanoMasaru MimuraKenji F. TanakaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
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Science Q Iku Tsutsui-Kimura Hiroyuki Takiue Keitaro Yoshida Ming Xu Ryutaro Yano Hiroyuki Ohta Hiroshi Nishida Youcef Bouchekioua Hideyuki Okano Motokazu Uchigashima Masahiko Watanabe Norio Takata Michael R. Drew Hiromi Sano Masaru Mimura Kenji F. Tanaka Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation |
description |
D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice. |
format |
article |
author |
Iku Tsutsui-Kimura Hiroyuki Takiue Keitaro Yoshida Ming Xu Ryutaro Yano Hiroyuki Ohta Hiroshi Nishida Youcef Bouchekioua Hideyuki Okano Motokazu Uchigashima Masahiko Watanabe Norio Takata Michael R. Drew Hiromi Sano Masaru Mimura Kenji F. Tanaka |
author_facet |
Iku Tsutsui-Kimura Hiroyuki Takiue Keitaro Yoshida Ming Xu Ryutaro Yano Hiroyuki Ohta Hiroshi Nishida Youcef Bouchekioua Hideyuki Okano Motokazu Uchigashima Masahiko Watanabe Norio Takata Michael R. Drew Hiromi Sano Masaru Mimura Kenji F. Tanaka |
author_sort |
Iku Tsutsui-Kimura |
title |
Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation |
title_short |
Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation |
title_full |
Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation |
title_fullStr |
Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation |
title_full_unstemmed |
Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation |
title_sort |
dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/db122104311e48c9b21cce00826f3e10 |
work_keys_str_mv |
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1718390024549957632 |