Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.

We used tensor-based morphometry (TBM) to: 1) map gray matter (GM) volume changes associated with motor learning in young healthy individuals; 2) evaluate if GM changes persist three months after cessation of motor training; and 3) assess whether the use of different schemes of motor training during...

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Autores principales:	Massimo Filippi, Antonia Ceccarelli, Elisabetta Pagani, Roberto Gatti, Alice Rossi, Laura Stefanelli, Andrea Falini, Giancarlo Comi, Maria Assunta Rocca
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db1297c36e474152b8c9c6ebcc650130
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spelling	oai:doaj.org-article:db1297c36e474152b8c9c6ebcc6501302021-11-25T06:24:31ZMotor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.1932-620310.1371/journal.pone.0010198https://doaj.org/article/db1297c36e474152b8c9c6ebcc6501302010-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20419166/?tool=EBIhttps://doaj.org/toc/1932-6203We used tensor-based morphometry (TBM) to: 1) map gray matter (GM) volume changes associated with motor learning in young healthy individuals; 2) evaluate if GM changes persist three months after cessation of motor training; and 3) assess whether the use of different schemes of motor training during the learning phase could lead to volume modifications of specific GM structures. From 31 healthy subjects, motor functional assessment and brain 3D T1-weighted sequence were obtained: before motor training (time 0), at the end of training (two weeks) (time 2), and three months later (time 3). Fifteen subjects (group A) were trained with goal-directed motor sequences, and 16 (group B) with non purposeful motor actions of the right hand. At time 1 vs. time 0, the whole sample of subjects had GM volume increase in regions of the temporo-occipital lobes, inferior parietal lobule (IPL) and middle frontal gyrus, while at time 2 vs. time 1, an increased GM volume in the middle temporal gyrus was seen. At time 1 vs. time 0, compared to group B, group A had a GM volume increase of the hippocampi, while the opposite comparison showed greater GM volume increase in the IPL and insula in group B vs. group A. Motor learning results in structural GM changes of different brain areas which are part of specific neuronal networks and tend to persist after training is stopped. The scheme applied during the learning phase influences the pattern of such structural changes.Massimo FilippiAntonia CeccarelliElisabetta PaganiRoberto GattiAlice RossiLaura StefanelliAndrea FaliniGiancarlo ComiMaria Assunta RoccaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 4, p e10198 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Massimo Filippi Antonia Ceccarelli Elisabetta Pagani Roberto Gatti Alice Rossi Laura Stefanelli Andrea Falini Giancarlo Comi Maria Assunta Rocca Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.
description	We used tensor-based morphometry (TBM) to: 1) map gray matter (GM) volume changes associated with motor learning in young healthy individuals; 2) evaluate if GM changes persist three months after cessation of motor training; and 3) assess whether the use of different schemes of motor training during the learning phase could lead to volume modifications of specific GM structures. From 31 healthy subjects, motor functional assessment and brain 3D T1-weighted sequence were obtained: before motor training (time 0), at the end of training (two weeks) (time 2), and three months later (time 3). Fifteen subjects (group A) were trained with goal-directed motor sequences, and 16 (group B) with non purposeful motor actions of the right hand. At time 1 vs. time 0, the whole sample of subjects had GM volume increase in regions of the temporo-occipital lobes, inferior parietal lobule (IPL) and middle frontal gyrus, while at time 2 vs. time 1, an increased GM volume in the middle temporal gyrus was seen. At time 1 vs. time 0, compared to group B, group A had a GM volume increase of the hippocampi, while the opposite comparison showed greater GM volume increase in the IPL and insula in group B vs. group A. Motor learning results in structural GM changes of different brain areas which are part of specific neuronal networks and tend to persist after training is stopped. The scheme applied during the learning phase influences the pattern of such structural changes.
format	article
author	Massimo Filippi Antonia Ceccarelli Elisabetta Pagani Roberto Gatti Alice Rossi Laura Stefanelli Andrea Falini Giancarlo Comi Maria Assunta Rocca
author_facet	Massimo Filippi Antonia Ceccarelli Elisabetta Pagani Roberto Gatti Alice Rossi Laura Stefanelli Andrea Falini Giancarlo Comi Maria Assunta Rocca
author_sort	Massimo Filippi
title	Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.
title_short	Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.
title_full	Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.
title_fullStr	Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.
title_full_unstemmed	Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.
title_sort	motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/db1297c36e474152b8c9c6ebcc650130
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_version_	1718413773506609152

Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study.

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