A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection

Abstract Platelet-rich plasma (PRP) is the most innovative blood-derived product used in regenerative medicine. We aimed to investigate the therapeutic efficacy of PRP urethral sphincter injection for the management of postprostatectomy incontinence (PPI). In total, 28 PPI patients with a mean age o...

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Autores principales:	Ping-Jui Lee, Yuan-Hong Jiang, Hann-Chorng Kuo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db1aa43c61e64ec894433a90663a4052
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spelling	oai:doaj.org-article:db1aa43c61e64ec894433a90663a40522021-12-02T13:19:30ZA novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection10.1038/s41598-021-84923-12045-2322https://doaj.org/article/db1aa43c61e64ec894433a90663a40522021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84923-1https://doaj.org/toc/2045-2322Abstract Platelet-rich plasma (PRP) is the most innovative blood-derived product used in regenerative medicine. We aimed to investigate the therapeutic efficacy of PRP urethral sphincter injection for the management of postprostatectomy incontinence (PPI). In total, 28 PPI patients with a mean age of 71.8 ± 8.9 years were prospectively enrolled. They received four PRP urethral sphincter injections each month. The clinical outcomes were assessed 3 months after the fourth injection as posttreatment Global Response Assessment (GRA) score, the newly designed visual analogue scale of stress urinary incontinence (VAS of SUI), and in urodynamic parameters. After injections, the posttreatment median GRA with quartiles was 2.0 (1.0, 2.0). Overall, six (21.4%) patients achieved complete continence and pad-free status, 20 (71.4%) achieved successful outcome (GRA score ≥ 2), and 26 (92.9%) showed clinical improvement (GRA score ≥ 1). The VAS of SUI significantly improved from 6.5 (5.0, 8.0) to 3.5 (2.0–5.8) (p < 0.001) as well as abdominal leak point pressure, from 57.5 (50.0, 115.0) to 126.0 (68.3, 150.0), (p = 0.004). After repeated PRP urethral sphincter injections, the SUI severity reduced significantly with high success rates. There was no major adverse event, except three patients with mild hematuria and micturition pain. In conclusion, PRP urethral sphincter injection is safe and effective as a novel management of PPI.Ping-Jui LeeYuan-Hong JiangHann-Chorng KuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ping-Jui Lee Yuan-Hong Jiang Hann-Chorng Kuo A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection
description	Abstract Platelet-rich plasma (PRP) is the most innovative blood-derived product used in regenerative medicine. We aimed to investigate the therapeutic efficacy of PRP urethral sphincter injection for the management of postprostatectomy incontinence (PPI). In total, 28 PPI patients with a mean age of 71.8 ± 8.9 years were prospectively enrolled. They received four PRP urethral sphincter injections each month. The clinical outcomes were assessed 3 months after the fourth injection as posttreatment Global Response Assessment (GRA) score, the newly designed visual analogue scale of stress urinary incontinence (VAS of SUI), and in urodynamic parameters. After injections, the posttreatment median GRA with quartiles was 2.0 (1.0, 2.0). Overall, six (21.4%) patients achieved complete continence and pad-free status, 20 (71.4%) achieved successful outcome (GRA score ≥ 2), and 26 (92.9%) showed clinical improvement (GRA score ≥ 1). The VAS of SUI significantly improved from 6.5 (5.0, 8.0) to 3.5 (2.0–5.8) (p < 0.001) as well as abdominal leak point pressure, from 57.5 (50.0, 115.0) to 126.0 (68.3, 150.0), (p = 0.004). After repeated PRP urethral sphincter injections, the SUI severity reduced significantly with high success rates. There was no major adverse event, except three patients with mild hematuria and micturition pain. In conclusion, PRP urethral sphincter injection is safe and effective as a novel management of PPI.
format	article
author	Ping-Jui Lee Yuan-Hong Jiang Hann-Chorng Kuo
author_facet	Ping-Jui Lee Yuan-Hong Jiang Hann-Chorng Kuo
author_sort	Ping-Jui Lee
title	A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection
title_short	A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection
title_full	A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection
title_fullStr	A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection
title_full_unstemmed	A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection
title_sort	novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db1aa43c61e64ec894433a90663a4052
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A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection

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