Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer

Abstract Lymphovascular invasion (LVI) and Black race are associated with poorer prognosis in early breast cancer (EBC). We evaluated the association between LVI and race, and whether LVI adds prognostic benefit to the 21-gene recurrence score (RS) in EBC. Women with ER+ HER2− EBC measuring up to 5 ...

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Auteurs principaux:	Della Makower, Juan Lin, Xiaonan Xue, Joseph A. Sparano
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Accès en ligne:	https://doaj.org/article/db1b4e3ce01c429cbcb8a0a40bb7e736
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spelling	oai:doaj.org-article:db1b4e3ce01c429cbcb8a0a40bb7e7362021-12-02T16:27:08ZLymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer10.1038/s41523-021-00231-x2374-4677https://doaj.org/article/db1b4e3ce01c429cbcb8a0a40bb7e7362021-03-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00231-xhttps://doaj.org/toc/2374-4677Abstract Lymphovascular invasion (LVI) and Black race are associated with poorer prognosis in early breast cancer (EBC). We evaluated the association between LVI and race, and whether LVI adds prognostic benefit to the 21-gene recurrence score (RS) in EBC. Women with ER+ HER2− EBC measuring up to 5 cm, with 0–3 involved axillary nodes, diagnosed between 1 January 2010 and 1 January 2014, who underwent surgery as first treatment and had available RS, were identified in the NCDB database. Bivariate associations between two categorical variables were examined using chi-square test. Multivariate Cox proportional hazards model were used to assess the association of LVI, race, and other covariates with overall survival (OS). 77,425 women, 65,018 node-negative (N0), and 12,407 with 1–3 positive (N+) nodes, were included. LVI was present in 12.7%, and associated with poor grade, RS 26–100, and N+ (all p < 0.0001), but not Black race. In multivariate analysis, LVI was associated with worse OS in N0 [HR 1.37 (95% CI 1.27, 1.57], but not N+ EBC. LVI was associated with worse OS in N0 patients with RS 11–25 [HR 1.31 (95% CI 1.09, 1.57)] and ≥26 [HR 1.58 (95% CI 1.30, 1.93)], but not RS 0–10. No interaction between LVI and chemotherapy benefit was seen. Black race was associated with worse OS in N0 (HR 1.21, p = 0.009) and N+ (HR 1.37, p = 0.015) disease. LVI adds prognostic information in ER+, HER2−, N0 BCA with RS 11–100, but does not predict chemotherapy benefit. Black race is associated with worse OS, but not LVI.Della MakowerJuan LinXiaonan XueJoseph A. SparanoNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Della Makower Juan Lin Xiaonan Xue Joseph A. Sparano Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer
description	Abstract Lymphovascular invasion (LVI) and Black race are associated with poorer prognosis in early breast cancer (EBC). We evaluated the association between LVI and race, and whether LVI adds prognostic benefit to the 21-gene recurrence score (RS) in EBC. Women with ER+ HER2− EBC measuring up to 5 cm, with 0–3 involved axillary nodes, diagnosed between 1 January 2010 and 1 January 2014, who underwent surgery as first treatment and had available RS, were identified in the NCDB database. Bivariate associations between two categorical variables were examined using chi-square test. Multivariate Cox proportional hazards model were used to assess the association of LVI, race, and other covariates with overall survival (OS). 77,425 women, 65,018 node-negative (N0), and 12,407 with 1–3 positive (N+) nodes, were included. LVI was present in 12.7%, and associated with poor grade, RS 26–100, and N+ (all p < 0.0001), but not Black race. In multivariate analysis, LVI was associated with worse OS in N0 [HR 1.37 (95% CI 1.27, 1.57], but not N+ EBC. LVI was associated with worse OS in N0 patients with RS 11–25 [HR 1.31 (95% CI 1.09, 1.57)] and ≥26 [HR 1.58 (95% CI 1.30, 1.93)], but not RS 0–10. No interaction between LVI and chemotherapy benefit was seen. Black race was associated with worse OS in N0 (HR 1.21, p = 0.009) and N+ (HR 1.37, p = 0.015) disease. LVI adds prognostic information in ER+, HER2−, N0 BCA with RS 11–100, but does not predict chemotherapy benefit. Black race is associated with worse OS, but not LVI.
format	article
author	Della Makower Juan Lin Xiaonan Xue Joseph A. Sparano
author_facet	Della Makower Juan Lin Xiaonan Xue Joseph A. Sparano
author_sort	Della Makower
title	Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer
title_short	Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer
title_full	Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer
title_fullStr	Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer
title_full_unstemmed	Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer
title_sort	lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db1b4e3ce01c429cbcb8a0a40bb7e736
work_keys_str_mv	AT dellamakower lymphovascularinvasionraceandthe21generecurrencescoreinearlyestrogenreceptorpositivebreastcancer AT juanlin lymphovascularinvasionraceandthe21generecurrencescoreinearlyestrogenreceptorpositivebreastcancer AT xiaonanxue lymphovascularinvasionraceandthe21generecurrencescoreinearlyestrogenreceptorpositivebreastcancer AT josephasparano lymphovascularinvasionraceandthe21generecurrencescoreinearlyestrogenreceptorpositivebreastcancer
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Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer

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